Results 121 to 130 of about 3,558 (177)

Cysteamine and cystamine

1987
Publisher Summary This chapter discusses about cysteamine and cystamine. Cysteamine (2-aminoethanethiol) is formed in mammalian tissues by the enzymatic hydrolysis of pantetheine, and has the role in the biosynthesis of hypotaurine. Cysteamine has been used therapeutically to treat cystinosis and sickle cell anemia, and has been used as a protective ...
M W, Duffel, D J, Logan, D M, Ziegler
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Interaction of Cystamine and Cystamine Derivatives with Nucleic Acids and Nucleoproteins

International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1965
SummaryThe disulphides–cystamine, bis (2-guanidoethyl) disulphide (GED), dimethylcystamine, tetramethylcystamine, tetraethyl cystamine, cystine dimethyl ester and cystine diethyl ester–have been shown to interact with and become reversibly bound to calf thymus DNA, E. ccli RNA, and to calf-thymus and rat-liver nucleoproteins.
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A Trial of Cystamine in Radiation Sickness

The British Journal of Radiology, 1960
A trial was made of the radioprotective substance, Cystamine, in radiation sickness. It did not prove more effective than lactose.
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Cystamine modulation of galactosamine-induced hepatotoxicity

Toxicology and Applied Pharmacology, 1984
The ability of cystamine treatment to protect against galactosamine-induced hepatic necrosis was investigated. Reduced hepatotoxicity was observed following galactosamine hydrochloride (400 mg/kg, ip) in male Sprague-Dawley rats that received cystamine dihydrochloride (300 mg/kg, po) 30 min prior to or 2, 4, 6, 8, or 12 hr after galactosamine.
J R, MacDonald, A J, Gandolfi, I G, Sipes   +2 more
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The effect of cystamine on gastric secretion in the rat

Agents and Actions, 1979
The effects of cystamine on gastric secretion were studied in conscious and anaesthetized rat preparations. In the conscious gastric fistula rat cystamine inhibited the basal acid output but increased pepsin output. This pepsinogogue action was inhibited by both atropine and metiamide.
M E, Parsons, K T, Bunce, A, Currington, F, Matheson, G, Pipkin   +4 more
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Mechanism for the inhibition of transglutaminase 2 by cystamine

Biochemical Pharmacology, 2005
Cystamine is neuroprotective in a number of models of neurodegeneration. The therapeutic benefit of cystamine has been attributed, in part, to its inhibition of transglutaminase activity. Cystamine [beta-mercaptoethanolamine (MEA) disulfide] is reduced within cells to MEA which is largely responsible for the in vivo effects of its disulfide precursor ...
Thomas M, Jeitner, E James, Delikatny, Jenny, Ahlqvist, Hugh, Capper, Arthur J L, Cooper   +4 more
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Application of Cystamine and N,N‘-Bis(glycyl)cystamine as Linkers in Polysaccharide−Protein Conjugation

Bioconjugate Chemistry, 1998
Pneumococcal polysaccharide type 6B, 14, or 23F (35-70 kDa) was activated with cyanogen bromide and modified with cystamine. After reduction of the spacer, the thiol-containing (i.e. cysteamine-modified) polysaccharide obtained was added in a 5-10-fold molar excess to bromoacetylated tetanus toxoid to give thioether-linked polysaccharide-protein ...
de Weers, O, Beurret, M, van Buren, L, Oomen, LA, Poolman, JT, Hoogerhout, P   +5 more
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Formation of 5-S-cystamine-5,6-dihydrothymine in radiolysis of aqueous solutions of thymine and cystamine

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1984
1. A method for synthesis of 5-S-cystamine-5,6-dihydrothymine was developed. 2. This compound is stable in neutral and acid solutions but rapidly decomposes according to a first-order reaction at pH 10–12. It was found that decomposition is due to acidbase dissociation of 5-S-cystamine-5,6-dihydrothymine (pK ∼ 11.1) and that the rate of ...
S. A. Grachev, E. V. Kropachev, G. I. Litvyakova   +2 more
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ChemInform Abstract: Synthesis of Cystamine.

ChemInform, 1991
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. D. BULAT, V. V. GRISHIN, T. E. KUZNETSOVA, S. V. NEKRASOV, B. V. PASSET   +4 more
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Electron Reactions in γ-Irradiated Thymidine and Cystamine

Nature, 1970
ALTHOUGH the technique of electron spin resonance (ESR) has been useful in the identification of some of the secondary radical species formed in γ-irradiated DNA and proteins, difficulties have been experienced in the interpretation of the spectra of the primary radiolytic products.
A D, Lenherr, M G, Ormerod
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