Results 31 to 40 of about 40,178 (264)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Invasive bladder cancer in the eighties: transurethral resection or cystectomy?

International Brazilian Journal of Urology, 2011
PURPOSE: Describe morbidity and survival in patients older than 80 years with muscle invasive bladder cancer (MIBC) treated with radical cystectomy (RC) or transurethral resection (TUR) in our institution.
Oscar Rodriguez Faba, Joan Palou, Guillermo Urdaneta, Luis Gausa, Humberto Villavicencio   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Implementation of the enhanced recovery after surgery protocol for radical cystectomy patients: A single centre experience [PDF]

Investigative and Clinical Urology
Purpose: The enhanced recovery after surgery (ERAS) protocol for radical cystectomy aims to facilitate postoperative recovery and hasten a return to normal daily activities.
Brendan A. Yanada, Brendan H. Dias, Niall M. Corcoran, Homayoun Zargar, Conrad Bishop, Sue Wallace, Diana Hayes, James G. Huang   +7 more
doaj   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Robot-assisted Radical Cystectomy with Orthotopic Neobladder (Pitcher Pot): Point of Technique [PDF]

Robot-assisted radical cystectomy with orthotopic neobladder reconstruction represents a significant advancement in the surgical management of muscle-invasive bladder carcinoma.
Nalin Kumar Shrivastava, Ankur Mittal, Vikas Kumar Panwar, Gautam Shubhankar   +3 more
core   +1 more source

How does the time interval between transurethral resection and cystectomy affect the oncological outcome after cystectomy in bladder cancer patients?

Urology Research and Practice, 2019
Objective: The time interval between transurethral resection (TUR) and cystectomy can vary substantially in patients with bladder cancer. We evaluated the time intervals between the first and last TURs and between the last TUR and cystectomy in an ...
Daniar Osmonov, Sidig Rehmann, Stefan Hautmann, Klaus Peter Juenemann   +3 more
doaj   +2 more sources

Indirect Comparison of Neoadjuvant Treatment Strategies for Muscle‐Invasive Bladder Cancer: ddMVAC and Perioperative Durvalumab‐Gemcitabine‐Cisplatin Versus Gemcitabine‐Cisplatin: A Systematic Review and Network Meta‐Analysis of Randomised Controlled Trials

International Journal of Cancer, EarlyView.
Optimizing neoadjuvant therapy for muscle‐invasive bladder cancer patients who are eligible for cisplatin remains difficult, owing particularly to high toxicity and recurrence rates. This meta‐analysis compared dose‐dense methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVAC) against durvalumab plus gemcitabine‐cisplatin (D‐GC) and GC alone ...
Maurin Helen Mangold, Gloria Baumann, Victoria Luise Simone Wieland, Nicolas Carl, Luisa Vivienne Renner, Alexander Studier‐Fischer, Hanna Menold, Stefanie Zschäbitz, Frederik Wessels, Niklas Westhoff, Maurice Stephan Michel, Karl‐Friedrich Kowalewski, Caelán Max Haney‐Aubert   +12 more
wiley   +1 more source

Standard cystectomy fits all: truth or myth?

, 2015
Radical cystectomy (RC) with pelvic lymph node dissection (PLND) followed by urinary diversion is the treatment of choice for muscle-invasive bladder cancer (BC) and non-invasive BC refractory to transurethral resection of the bladder (TUR-B) and/or ...
Roth, Beat, Roth, B., Thalmann, G.N., Thalmann, George   +3 more
core   +1 more source

Outcome of orthotopic sigmoid versus ileal neobladder reconstruction

Urology Annals, 2019
Introduction: Radical cystectomy with orthotopic urinary diversion is considered the gold standard for treatment of muscular invasive bladder cancer or high-risk nonmuscular invasive bladder cancer.
Hisham Abdulazim El-Helaly, Mohamed Kamal Saifelnasr, Khaled Mohyeelden Mohamed, Alsayed Saad Abdelaziz, Hamada Ahmed Youssof   +4 more
doaj   +1 more source