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Inhibitors of Cysteine Proteases
Current Topics in Medicinal Chemistry, 2006The roles of cysteine proteases (CP) as protein degrading and protein processing enzymes both in physiological and pathological processes of mammals are well known. Furthermore, the key roles of CP;s in the life cycles of infectious agents like protozoa and viruses turn them into new important targets for anti-infective drugs.
Tanja Schirmeister +3 more
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Drug Metabolism Reviews, 2012
S-carboxymethyl-L-cysteine, the side-chain carboxymethyl derivative of the sulfur-containing amino acid, cysteine, has been known and available for almost 80 years. During this time, it has been put to a variety of uses, but it is within the field of respiratory medicine that, presently, it has found a clinical niche.
Mitchell, SC, Steventon, GB
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S-carboxymethyl-L-cysteine, the side-chain carboxymethyl derivative of the sulfur-containing amino acid, cysteine, has been known and available for almost 80 years. During this time, it has been put to a variety of uses, but it is within the field of respiratory medicine that, presently, it has found a clinical niche.
Mitchell, SC, Steventon, GB
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THE LYSOSOMAL CYSTEINE PROTEASES
Annual Review of Biophysics and Biomolecular Structure, 1999▪ Abstract A significant number of exciting papain-like cysteine protease structures have been determined by crystallographic methods over the last several years. This trove of data allows for an analysis of the structural features that empower these molecules as they efficiently carry out their specialized tasks.
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Progress in Neurobiology, 2020
Cysteine string protein (CSP) was discovered by use of a synapse-specific, monoclonal antibody to screen a cDNA expression library in Drosophila. A vertebrate CSP homolog was later identified and shown to co-purify with synaptic vesicles. CSP-α is now recognized as a membrane constituent of many regulated secretory organelles.
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Cysteine string protein (CSP) was discovered by use of a synapse-specific, monoclonal antibody to screen a cDNA expression library in Drosophila. A vertebrate CSP homolog was later identified and shown to co-purify with synaptic vesicles. CSP-α is now recognized as a membrane constituent of many regulated secretory organelles.
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The interaction of aurothiomalate and cysteine
Biochemical Pharmacology, 1976Abstract Aurothiomalate and cysteine react under appropriate conditions to produce an insoluble complex of aurocysteine. Although alkylation of the SH group of cysteine completely blocks the reaction, the organomercurials have no effect. The results are compared with, and found to be compatible with, the interaction between aurothiomalate and the ...
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2019
Preparation of antibody-drug conjugates (ADCs) with a highly homogeneous drug loading in general requires site-selective conjugation of a cytotoxic payload. Typically, functionality utilized for attachment of the payload is achieved through engineering of suitable chemical handles or by enzymatic modification of the antibody.
João M. Nunes +2 more
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Preparation of antibody-drug conjugates (ADCs) with a highly homogeneous drug loading in general requires site-selective conjugation of a cytotoxic payload. Typically, functionality utilized for attachment of the payload is achieved through engineering of suitable chemical handles or by enzymatic modification of the antibody.
João M. Nunes +2 more
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A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Nature, 1992N. Thornberry +28 more
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S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate
Nature Chemical Biology, 2019Wei Qin +12 more
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Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism.
Angewandte Chemie, 2018Feng Li +8 more
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