Results 281 to 290 of about 352,696 (330)

Acute Pericarditis in an Adult with Cystic Fibrosis: A Case Report and Literature Review. [PDF]

Eur J Case Rep Intern Med
Abu-Shanab A, Tayyeb M, Saad Anwar M, Aquino DA, Amog P, Shubietah A, Du D.   +6 more
europepmc   +1 more source

Opportunities of patient‐derived organoids in drug development

British Journal of Pharmacology, EarlyView.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

Pancreatic Status Is Not a Risk Factor for Cystic Fibrosis-Related Bone Disease. [PDF]

Pediatr Pulmonol
Dotan M, Trau M, Mei-Zahav M, Mussaffi H, Gendler Y, Blau H, Prais D.   +6 more
europepmc   +1 more source

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye, Claire Pearson, Tibyan Babiker, Emilio Agostinelli, Rumaitha Al‐Hosni, Paolo Tammaro   +5 more
wiley   +1 more source

Short-term stability of the sputum microbiota in bronchiectasis and cystic fibrosis. [PDF]

ERJ Open Res
Richardson H, Keir HR, Nitza S, Fong CJ, Crichton ML, Dicker AJ, Chalmers JD.   +6 more
europepmc   +1 more source

Inhibitory Effects of 3′,4′‐Dihydroxyflavonol in a Rabbit Model of Minimally Invasive Bleb Surgery With PreserFlo MicroShunt

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background The success of minimally invasive bleb surgery (MIBS) such as the PreserFlo MicroShunt (PFMS) is limited by post‐operative bleb fibrosis. Current clinical practice prescribes the use of off‐label cytotoxic antimetabolites such as Mitomycin C (MMC) as antifibrotic therapy.
Zoe Pasvanis, Roy C. K. Kong, Elsa C. Chan, Jennifer C. Fan Gaskin   +3 more
wiley   +1 more source

Caries in a cohort of adults with cystic fibrosis: a cross-sectional study. [PDF]

Br Dent J
O Leary F, Coffey N, Burke FM, Roberts A, Kirwan L, O Regan P, Plant B, Hayes M.   +7 more
europepmc   +1 more source

Beyond Carrier Status: CFTR Heterozygosity as an Overlooked Clinical Risk Factor for Pancreatitis

Clinical Genetics, EarlyView.
CFTR carrier status detected via prenatal screening is associated with increased pancreatitis risk in women, but clinical recognition remains low. Integrating carrier results into electronic health records may enhance personalized care and aid in early diagnosis. ABSTRACT This study assessed the effect of CFTR pathogenic variant status, detected during
Lucas D. Richter, Douglas M. Ruderfer, Josh F. Peterson, Lisa A. Bastarache   +3 more
wiley   +1 more source

ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis. [PDF]

Nucleic Acids Res
Ko W, Porter JJ, Spelier S, Sorensen EG, Bhatt P, Gabell JT, van der Windt I, Couch T, Coote K, Mense M, Beekman JM, Lueck JD.   +11 more
europepmc   +1 more source

Anaphylaxis Induced by Goat's and Sheep's Milk: An Allergen That We Should Keep Under Surveillance

Allergy, EarlyView.
Guillaume Pouessel, Elleni‐Sofia Vaia, Catharina Chatain, Valérie Liabeuf, Camille Braun, Anne‐Karine Correard, Elena Bradatan, Pascale Dumond, Yasemin Karaca‐Altintas, Pascale Beaumont, Delphine Delalande, Sélina Tscheiller, Xavier Van der Brempt, Carine Metz‐Favre, Amandine Divaret‐Chauveau, Dominique Sabouraud‐Leclerc   +15 more
wiley   +1 more source