Results 71 to 80 of about 352,696 (330)

Recent Advances in mRNA Delivery Systems for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang   +9 more
wiley   +1 more source

Increased fat mass and obesity risk after elexacaftor–tezacaftor–ivacaftor therapy in young adults with cystic fibrosis

open access: yesFrontiers in Nutrition
BackgroundWhen people with cystic fibrosis (PwCFs) are treated with cystic fibrosis transmembrane conductance regulator protein modulator (CFTRm), it leads to changes in body composition.
Ana Merino Sánchez-Cañete   +6 more
doaj   +1 more source

A retrospective analysis of longitudinal changes in bone mineral content in cystic fibrosis [PDF]

open access: yes, 2017
Background: We aimed to describe the longitudinal changes in bone mineral content and influencing factors, in children with cystic fibrosis (CF). Methods: One hundred children (50 females) had dual X-ray absorptiometry (DXA) performed.
Ahmed, Syed Faisal   +7 more
core   +1 more source

Investigating the Temporal Relationships between Symptoms and Nebuliser Adherence in People with Cystic Fibrosis: A Series of N-of-1 Observations [PDF]

open access: yes, 2020
Treatment adherence in adults with cystic fibrosis (CF) is poor. One of the reasons identified for lack of adherence to nebulised treatments is that patients may not experience any immediate relief in their symptoms or notice changes as a result of ...
Arden, Madelynne   +4 more
core   +2 more sources

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

open access: yesAdvanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu   +9 more
wiley   +1 more source

A smartphone app for preschool wheezing and reliability of medical history collection

open access: yesItalian Journal of Pediatrics
Background The use of mobile applications helps improving self-management in adolescents with asthma. However, no evidence is available for children with preschool wheezing.
Nicola Ullmann   +7 more
doaj   +1 more source

Lung function improvement on triple modulators: high-resolution, nationwide data from the Danish Cystic Fibrosis Cohort

open access: yesERJ Open Research
Background People living with cystic fibrosis in Denmark had early, universal access to triple modulator treatment with elexacaftor/tezacaftor/ivacaftor.
Christian Leo-Hansen   +19 more
doaj   +1 more source

MRSA eradication of newly acquired lower respiratory tract infection in cystic fibrosis [PDF]

open access: yes, 2016
UK cystic fibrosis (CF) guidelines recommend eradication of methicillin-resistant Staphylococcus aureus (MRSA) when cultured from respiratory samples.
Downey, DG   +7 more
core   +3 more sources

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

open access: yesAdvanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen   +6 more
wiley   +1 more source

The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway

open access: yesScientific Reports, 2022
Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the endoplasmic reticulum (ER).
Graeme W. Carlile   +9 more
doaj   +1 more source

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