Results 71 to 80 of about 925,943 (256)
Frontiers in NutritionBackgroundWhen people with cystic fibrosis (PwCFs) are treated with cystic fibrosis transmembrane conductance regulator protein modulator (CFTRm), it leads to changes in body composition.
Ana Merino Sánchez-Cañete +6 more
doaj +1 more source
Scientific Reports, 2022 Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the endoplasmic reticulum (ER).
Graeme W. Carlile +9 more
doaj +1 more source
ERJ Open ResearchBackground People living with cystic fibrosis in Denmark had early, universal access to triple modulator treatment with elexacaftor/tezacaftor/ivacaftor.
Christian Leo-Hansen +19 more
doaj +1 more source
Comparing Online Community Structure of Patients of Chronic Diseases [PDF]
arXiv, 2015 In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.
arxiv
Claim Detection in Biomedical Twitter Posts [PDF]
arXiv, 2021 Social media contains unfiltered and unique information, which is potentially of great value, but, in the case of misinformation, can also do great harm. With regards to biomedical topics, false information can be particularly dangerous. Methods of automatic fact-checking and fake news detection address this problem, but have not been applied to the ...
arxiv
Small molecule ion channels increase host defenses in cystic fibrosis airway epithelia
Nature, 2019 Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) compromise epithelial HCO3− and Cl− secretion, reduce airway surface liquid pH, and impair respiratory host defences in people with cystic fibrosis1–3.
Katrina A. Muraglia +11 more
semanticscholar +1 more source
A factor graph EM algorithm for inference of kinetic microstates from patch clamp measurements [PDF]
arXiv, 2021 We derive a factor graph EM (FGEM) algorithm, a technique that permits combined parameter estimation and statistical inference, to determine hidden kinetic microstates from patch clamp measurements. Using the cystic fibrosis transmembrane conductance regulator (CFTR) and nicotinic acetylcholine receptor (nAChR) as examples, we perform {\em Monte Carlo}
arxiv
Boosting Joint Models for Longitudinal and Time-to-Event Data [PDF]
arXiv, 2016 Joint Models for longitudinal and time-to-event data have gained a lot of attention in the last few years as they are a helpful technique to approach common a data structure in clinical studies where longitudinal outcomes are recorded alongside event times.
arxiv
Bayesian Quantile-Based Joint Modelling of Repeated Measurement and Time-to-Event data, with an Application to Lung Function Decline and Time to Infection in Patients with Cystic Fibrosis [PDF]
arXiv, 2016 Background: The most widely used approach to joint modelling of repeated measurement and time to event data is to combine a linear Gaussian random effects model for the repeated measurements with a log-Gaussian frailty model for the time-to-event outcome, linking the two through some form of correlation structure between the random effects and the log ...
arxiv
A Novel Tool to Evaluate the Accuracy of Predicting Survival in Cystic Fibrosis [PDF]
arXiv, 2017 Background: Effective allocation of limited donor lungs in cystic fibrosis (CF) requires accurate survival predictions, so that high-risk patients may be prioritized for transplantation. In practice, decisions about allocation are made dynamically, using routinely updated assessments.
arxiv