Results 71 to 80 of about 486,806 (280)
Advanced Science, EarlyView.This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li +8 more
wiley +1 more source
Comparison of NONMEM and pmetrics analysis for aminoglycosides in adult patients with cystic fibrosis [PDF]
, 2013 The aim of this study was to compare the performance of parametric and nonparametric approaches in population pharmacokinetic analysis for cystic fibrosis patients. The study involved a retrospective analysis of a database of aminoglycoside concentration
Thomson, Alison
core +2 more sources
A smartphone app for preschool wheezing and reliability of medical history collection
Italian Journal of PediatricsBackground The use of mobile applications helps improving self-management in adolescents with asthma. However, no evidence is available for children with preschool wheezing.
Nicola Ullmann +7 more
doaj +1 more source
ERJ Open ResearchBackground People living with cystic fibrosis in Denmark had early, universal access to triple modulator treatment with elexacaftor/tezacaftor/ivacaftor.
Christian Leo-Hansen +19 more
doaj +1 more source
Standards for the care of people with cystic fibrosis; establishing and maintaining health [PDF]
Cystic fibrosis; Health; StandardsFibrosis quística; Salud; EstándaresFibrosi quística; Salut; EstàndardsThis is the second in a series of four papers updating the European Cystic Fibrosis Society (ECFS) standards for the care of people with CF.
Southern, Kevin +6 more
core +1 more source
Advanced Science, EarlyView.During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu +14 more
wiley +1 more source
Cystic Fibrosis Registry of Ireland: annual report, 2003
, 2003 The field of cystic fibrosis is a complex and intricate one. All of the professionals who work in this field realise that they are dependent on each other in order to be effective.
Cystic Fibrosis Registry of Ireland
core
Advanced Science, EarlyView.This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun +12 more
wiley +1 more source
Magnetic Resonance Reveals Radical Stability in Native Biofilms and Its Role in Bacterial Resistance
Angewandte Chemie, EarlyView.The complex biofilm environment consists of planktonic bacterial cells and cells embedded in an extracellular matrix (ECM). Through an integrated magnetic resonance approach, we show that nitroxide radicals primarily interact with the polysaccharides and lipids in the ECM.
Alysia Mandato +10 more
wiley +2 more sources
Expanding the Phenotypic Spectrum of TXNDC15‐Related Ciliopathies to Include Joubert Syndrome
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Biallelic loss‐of‐function variants in TXNDC15 are a known cause of the perinatally lethal ciliopathy Meckel syndrome (MKS). TXNDC15 encodes an endoplasmic reticulum (ER)‐resident thioredoxin‐domain protein required for ciliary transition zone integrity.
Zachary T. Sentell +16 more
wiley +1 more source