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Antineoplastic Activity of Sodium Caseinate in a Cytarabine-Resistant Mouse Acute Myeloid Leukemia Cell Line. [PDF]

Nutrients
Aguiñiga-Sánchez I, Ledesma-Martínez E, Vázquez-Guerrero M, Hernández-Álvarez D, Velasco-García A, Rodríguez-Terán KM, Romero-Trejo D, Mendoza-Núñez VM, Macías-Zaragoza VM, Santiago-Osorio E.   +9 more
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Cytarabine ears – A side effect of cytarabine therapy

Journal of Oncology Pharmacy Practice, 2019
Cytarabine, a pyramidine analog, is used for treating various hematological malignancies such as acute leukemias and lymphomas. Side effects of cytarabine are dose dependent and include bone marrow suppression, fever, cerebellar toxicity, cardiomyopathy, hepato-renal insufficiency, necrotizing enterocolitis, pancreatitis, acute respiratory distress ...
Divya Doval, Sanjeev Kumar Sharma, Meet Kumar, Vipin Khandelwal, Dharma Choudhary   +4 more
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Cytarabine

Journal of Pediatric Oncology Nursing, 1990
Cytarabine is effective in the treatment of leukemias and CNS disease when given SQ, IM, IV, or intrathecally. Research is continuing to investigate high-dose therapy with cytarabine.
D L, Betcher, N, Burnham
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Cytarabine and neurologic toxicity. [PDF]

Journal of Clinical Oncology, 1991
Cytarabine is an effective drug in the treatment of certain hematologic malignancies and its common toxicities are myelosuppression and gastrointestinal disturbance. In the past decade, neurotoxicity has been an increasingly recognized cytarabine effect. Intrathecal (IT) cytarabine may result in myelopathy that is incompletely reversible.
R B Weiss, G L Royer, W J Baker
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Deoxycytidine Kinase (DCK) Mutations in Human Acute Myeloid Leukemia Resistant to Cytarabine

Acta Haematologica, 2021
Resistance to cytarabine is an important cause of therapy failure in persons with acute myeloid leukemia (AML). Deoxycytidine kinase, encoded by DCK, catalyzes phosphorylation of cytarabine to cytarabine monophosphate, a necessary step for eventual ...
Biao Wu, Z. Mao, Zhi Wang, Pin Wu, Hongyu Huang, Wenjun Zhao, Lei Zhang, Zhou Zhang, Hongchao Yin, R. Gale, Bin Yin   +10 more
semanticscholar   +1 more source

Bexarotine and Cytarabine, Liposomal [PDF]

Hospital Pharmacy, 2000
The increasing complexity of cancer chemotherapy makes it mandatory that pharmacists be familiar with these highly toxic agents. This column examines issues related to the preparation, dispensing, and administration of cancer chemotherapy and reviews agents, both commercially available and investigational, used to treat malignant diseases.
Dominic A. Solimando, J. Aubrey Waddell
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Development and application of a rapid and sensitive liquid chromatography-mass spectrometry method for simultaneous analysis of cytarabine, cytarabine monophosphate, cytarabine diphosphate and cytarabine triphosphate in the cytosol and nucleus

Journal of Pharmaceutical and Biomedical Analysis, 2022
In this study, a sensitive and rapid ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous analysis of cytarabine (ara-C), cytarabine monophosphate (ara-CMP), cytarabine diphosphate (ara-CDP) and cytarabine triphosphate (ara-CTP) in the cytosol and nucleus.
Shenjia, Huang, Linsheng, Liu, Xiaoxue, Liu, Lin, Song, Chenrong, Huang, Liyan, Miao   +5 more
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Cytarabine for Herpesvirus Infections

JAMA: The Journal of the American Medical Association, 1972
The antileukemic agent cytarabine has recently been used to treat herpesvirus infections, but the regimens advocated for this purpose are high-dose prolonged infusions (100 mg/sq m of body surface per day for five days). The use of cytarabine as an antiviral agent has been restricted by the toxic effects produced with these regimens.
William Hryniuk, Anthony Chow, John Foerster, Majid Shojania   +3 more
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A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

Advanced Functional Materials, 2018
Zeolitic imidazolate framework‐8 (ZIF‐8) is an attractive metal organic framework (MOF) in drug delivery. Strong interaction between drugs and ZIF‐8 is essential for high drug loadings through in situ construction of MOFs.
Huiyuan Zhang, Qian Li, Ruiling Liu, Xinke Zhang, Zhonghao Li, Y. Luan   +5 more
semanticscholar   +1 more source

The Toxicity of Cytarabine

Drug Safety, 1990
The principal toxicity of standard induction regimens for acute non-lymphocytic leukemia (ANLL) [including cytarabine (ARA-C) 100 mg/m2 for 7 days plus an anthracycline] is myelotoxicity, leading to death in at least 25% of cases during induction in non-selected patients.
openaire   +3 more sources