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Febrile Response to Cytarabine
JAMA: The Journal of the American Medical Association, 1974To the Editor.— During our increased utilization of cytarabine (Cytosar) especially in therapy of acute leukemia, we noted that four of approximately 105 of our patients treated had recurrent febrile responses during therapy with the drug. This fever may be either a single spike reaching 38 to 39 C (100 to 102 F) in an otherwise afebrile patient, or ...
Dale B. Kellon +3 more
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Clinical Pharmacokinetics of Cytarabine Formulations [PDF]
Clinical Pharmacokinetics, 2002 Cytarabine (cytosine arabinoside, Ara-C) is an effective chemotherapeutic agent for the treatment of acute myelogenous leukaemia and lymphocytic leukaemias. As cytarabine is an S-phase-specific drug, prolonged exposure of cells to cytotoxic concentrations is critical to achieve maximum cytotoxic activity.
Masahiro Nakano +2 more
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2009
Publisher Summary This chapter describes cytarabine, its nomenclature, formulae, preparation methods, physical characteristics, analytical methods, biological analysis, pharmacokinetics, metabolism, stability, and pharmacology. Cytarabine, a pyrimidine nucleoside analog, is an antimetabolite, antineo-plastic, which inhibits the synthesis of ...
Hussein I. El-Subbagh +1 more
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Publisher Summary This chapter describes cytarabine, its nomenclature, formulae, preparation methods, physical characteristics, analytical methods, biological analysis, pharmacokinetics, metabolism, stability, and pharmacology. Cytarabine, a pyrimidine nucleoside analog, is an antimetabolite, antineo-plastic, which inhibits the synthesis of ...
Hussein I. El-Subbagh +1 more
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Cytarabine Dose for Acute Myeloid Leukemia
New England Journal of Medicine, 2011Cytarabine (ara-C) is an important drug in the treatment of acute myeloid leukemia (AML). High-dose cytarabine (2000 to 3000 mg per square meter of body-surface area) is toxic but results in higher rates of relapse-free survival than does the conventional dose of 100 to 400 mg per square meter.
Löwenberg, B +17 more
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Clinical Pharmacology & Therapeutics, 1970
Warning. Only physicians experienced in cancer chemotherapy should use Cytosar. For induction therapy patients should be hospitalized in a facility with laboratory and supportive resources sufficient to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity.
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Warning. Only physicians experienced in cancer chemotherapy should use Cytosar. For induction therapy patients should be hospitalized in a facility with laboratory and supportive resources sufficient to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity.
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Synthesis of radiolabeled cytarabine conjugates
Bioorganic & Medicinal Chemistry Letters, 2009N4-Modified, novel Ara-C conjugate capable of radiolabeling with gamma ray-emitting ((99m)Tc) as well as positron emitting ((18)F) radionuclides, that is, N4-hydrazine derivative was synthesized. The radiolabeling of N4-(hydrazinonicotinyl)-1-beta-arabinofuranosyl cytosine (HAra-C) with (99m)Tc was performed with over 95% labeling yield.
Prachi Vilekar +2 more
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Archives of Pediatrics & Adolescent Medicine, 1988
In Reply .—Dr Slater indicates that the symptoms and signs of the patient we recently described may not have been caused by generalized anaphylaxis but rather by hypoglycemia or hypocalcemia. The most likely alternative diagnosis, we believe, would have been a vasovagal attack 1,2 ; however, none of these conditions would have resulted in swelling of ...
Michael C. Greeff +5 more
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In Reply .—Dr Slater indicates that the symptoms and signs of the patient we recently described may not have been caused by generalized anaphylaxis but rather by hypoglycemia or hypocalcemia. The most likely alternative diagnosis, we believe, would have been a vasovagal attack 1,2 ; however, none of these conditions would have resulted in swelling of ...
Michael C. Greeff +5 more
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Effects of high-dose cytarabine
Clinical Pharmacology and Therapeutics, 1982Plasma, urine, cerebrospinal fluid, and tear concentrations of cytarabine (ara-C) were measured in 15 patients receiving 3 gm/m2 IV ara-C given as a 1 hr infusion every 12 hr for 6 days. The two assay methods used for measuring ara-C concentrations (high-pressure liquid chromatography and radioimmunoassay) gave much the same results.
Steven N. Wolff +9 more
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Corneal Toxicity with Systemic Cytarabine
American Journal of Ophthalmology, 1981Three patients with leukemia developed corneal toxicity while receiving high doses (3 g/m2) of systemic cytarabine. Symptoms began five to seven days after initiation of treatment with high doses of systemic cytarabine and consisted of ocular pain, tearing, foreign-body sensation, photophobia, and blurred vision.
Bruce L. Johnson +3 more
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Cytarabine and daunorubicin for the treatment of acute myeloid leukemia
Expert Opinion on Pharmacotherapy, 2017Introduction: Acute myeloid leukemia (AML) is the most common acute forms of leukemia in adults. It has a poor long-term survival with a high relapse rate and at relapse, is commonly resistant to available therapies.
T. Murphy, K. Yee
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