Results 271 to 280 of about 51,607 (296)

Pharmacogenomics of Cytarabine in Childhood Leukemia

Pharmacogenomics, 2011
Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow characterized by uncontrolled proliferation of hematopoietic precursor cells with impaired hematopoiesis leading to neutropenia, anemia and thrombo­ cytopenia. AML is the second most common pediatric leukemia and has the worst prognosis of all major childhood cancers, more than one ...
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Palmar-Plantar Erythrodysesthesia and Cytarabine

Annals of Internal Medicine, 1985
Excerpt To the editor: Lokich and Moore (1) have reported the occurrence of the palmar-plantar erythrodysesthesia syndrome in patients receiving continuous infusion chemotherapy.
Lloyd E. King, Steven N. Wolff, Maria R. Baer   +2 more
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Use of Cytarabine for Herpesvirus Infections

Archives of Dermatology, 1972
To the Editor.— Cytarabine ( Cytosar ), an anti-cancer drug, administered for herpesvirus infection appears to be a new, useful therapy for simplex and zoster-varicella. 1 As indicated in the article, the immunosuppressive and cytotoxic qualities of this drug will require careful monitoring.
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A randomized phase III study of standard versus high-dose cytarabine with or without vorinostat for AML

Leukemia, 2023
G. Garcia-Manero, N. Podoltsev, M. Othus, J. Pagel, J. Radich, Min Fang, D. Rizzieri, Guido Marcucci, S. Strickland, M. Litzow, M. L. Savoie, Bruno C. Medeiros, M. Sekeres, Tara L Lin, G. Uy, B. Powell, J. Kolitz, Richard A. Larson, R. Stone, David F Claxton, J. Essell, S. Luger, Sanjay R. Mohan, A. Moseley, Frederick R. Appelbaum, H. Erba   +25 more
semanticscholar   +1 more source

Devimistat in combination with high dose cytarabine and mitoxantrone compared with high dose cytarabine and mitoxantrone in older patients with relapsed/refractory acute myeloid leukemia: ARMADA 2000 Phase III study.

Future Oncology, 2019
Devimistat (CPI-613®) is an intravenously administered, novel lipoate analog that inhibits two key tricarboxcylic acid (TCA) cycle enzymes, pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase complexes (KGDH). These complexes control TCA cycle
T. Pardee, S. Luther, M. Buyse, B. Powell, J. Cortes   +4 more
semanticscholar   +1 more source

Synthetic Approaches to a Mononucleotide Prodrug of Cytarabine

Nucleosides, Nucleotides & Nucleic Acids, 2005
Synthetic pathways to a mononucleotide prodrug of cytarabine (Ara-C) bearing S-pivaloyl-2-thioethyl (tBuSATE) groups, as biolabile phosphate protections, are reported. Using a common phosphoramidite approach, two different kinds of nucleoside protecting groups have been investigated. During this study, we observed an intermolecular migration of the Boc
BAZZANINI R., GOUY M. H., PEYROTTES S., GOSSELIN G., PERIGAUD C., MANFREDINI, Stefano   +5 more
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Mitoxantrone and cytarabine versus daunorubicin and cytarabine in previously untreated patients with acute myeloid leukemia

Cancer Chemotherapy and Pharmacology, 1991
A total of 44 adults aged 18-78 years were allocated to an open randomized study whose aim was to compare the efficacy and toxicity of mitoxantrone with those of daunorubicin in previously untreated patients presenting with acute myeloid leukemia.
Michael Hedenus, Per Hörnsten, Anders Wahlin, Claes Malm   +3 more
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Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia

Nature Cancer, 2021
Claudie Bosc, E. Saland, Aurélie Bousard, Noémie Gadaud, Marie Sabatier, Guillaume Cognet, Thomas Farge, Emeline Boet, Mathilde Gotanègre, Nesrine Aroua, P. Mouchel, Nathan Polley, C. Larrue, E. Kaphan, M. Picard, Ambrine Sahal, Latifa Jarrou, M. Tosolini, F. Rambow, F. Cabon, N. Nicot, Laura Poillet-Perez, Yujue Wang, Xiaoyang Su, Quentin Fovez, J. Kluza, R. Argüello, C. Mazzotti, H. Avet-Loiseau, F. Vergez, J. Tamburini, J. Fournié, I. Tiong, A. Wei, T. Kaoma, J. Marine, C. Récher, Lucille Stuani, Carine Joffre, J. Sarry   +39 more
semanticscholar   +1 more source

Generalized benign cutaneous reaction to cytarabine

Journal of the American Academy of Dermatology, 2015
Cytarabine-induced toxicity manifests as various cutaneous morphologies. A generalized papular purpuric eruption has not been well described.We aimed to characterize a distinct cytarabine-related eruption.We reviewed all cases of cytarabine-related toxicity with papular purpuric eruptions or violaceous erythema at the University of California, San ...
Beth S. Ruben, Sam V Truong, Lindy P. Fox, Wesley Y. Yu, Fan Liu, Kevin C. Wang   +5 more
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Progressive multifocal leukoencephalopathy-remission with cytarabine

Journal of Infection, 1990
A 51-year-old woman who was in complete remission from non-Hodgkin's lymphoma, developed a rapidly progressive dementia. Progressive multifocal leukoencephalopathy (PML) was diagnosed on the basis of a rising antibody titre to JC polyomavirus in cerebro-spinal fluid and serum and the presence of diffuse white matter changes on magnetic resonance ...
T. O'Riordan, Michael Hutchinson, P. A. Daly, A. G. Shattock, S. D. Gardner   +4 more
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