Results 241 to 250 of about 383,545 (307)

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Effect of esomeprazole on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader, in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study is to evaluate the effects of multiple doses of esomeprazole, a strong proton pump inhibitor and acid‐reducing agent, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader.
Lana Tran, Naihan Chen, Jennifer A. Winton, Kyle T. Matschke, Smita P. Goodman, Kimberly C. Lee, Yuanyuan Zhang, Weiwei Tan   +7 more
wiley   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Proteomics, modeling, and fluorescence assays delineate cytochrome b₅ residues involved in binding and stimulation of cytochrome P450 17A1 17,20-lyase. [PDF]

J Biol Chem
Tateishi Y, Webb SN, Li B, Liu L, Lindsey Rose K, Leser M, Patel P, Guengerich FP.   +7 more
europepmc   +1 more source

Cytochrome b₅ reductase 3 overexpression and dietary nicotinamide riboside supplementation promote distinctive mitochondrial alterations in distal convoluted tubules of mouse kidneys during aging. [PDF]

Aging Cell
Pérez-Rodríguez M, García-Verdugo A, Sánchez-Mendoza LM, Muñoz-Martín A, Bolaños N, Pérez-Sánchez C, Moreno JA, Burón MI, de Cabo R, González-Reyes JA, Villalba JM.   +10 more
europepmc   +1 more source

Isolation of cytochrome b form the cytochrome b/c1 complex of Rhodopseudomonas sphaeroides GA

, 1983
The purification and the biochemical characterization of cytochrome b of the cytochrome b/c1 complex from Rhodobacter capsulatus is reported.
GABELLINI, NADIA, HAUSKA G.
openaire   +2 more sources

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Reduction kinetics of cytochromes b

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1972
Abstract 1. 1. Durohydroquinone (H2DQ), a specific reductant for the second phosphorylation site, has been used in the study of the fast reduction kinetics of cytochromes b. 2. 2. In ubiquinone-extracted mitochondria, H2DQ reduces cytochrome(s) b in a fast reaction, the rate and extent of which decreases upon reincorporation of ubiquinone ...
A, Boveris, M, Erecińska, M, Wagner
openaire   +2 more sources

Mammalian Cytochrome b

Science, 1959
Digestion of a preparation of cytochromes b and c 1 with pancreatic protease followed by ammonium sulfate precipitation resulted in a soluble cytochrome b uncontaminated by cytochrome c 1 .
D, FELDMAN, W W, WAINIO
openaire   +2 more sources

On the Structure and Function of Cytochrome b-559

Photosynthesis Research, 1986
A sumary of biochemical, biophysical, and molecular biological data is presented which led to the identification of two different polypeptides (α and β, MW=9.16 and 4.27 kDa) in the cytochrome b-559 protein. The presence of a single His residue on each polypeptide, and the conclusion from spectroscopy that the heme coordination must be bis-histidine ...
W A, Cramer, S M, Theg, W R, Widger
openaire   +2 more sources