Results 141 to 148 of about 29,283 (148)

Metabolism of N-nitrosobenzylmethylamine by human cytochrome P-450 enzymes.

Journal of Toxicology and Environmental Health, Part A, 1999
N-Nitrosobenzylmethylamine (NBzMA) is a potent esophageal carcinogen in rodents, and has been found as a dietary contaminant in certain areas of China where esophageal cancer is endemic. To determine which cytochrome P-450 enzymes in humans are primarily
M. Morse, Jerry Lu, G. Stoner, S. Murphy, L. Peterson   +4 more
semanticscholar   +1 more source

Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: an update.

Current drug metabolism, 2002
The selective serotonin reuptake inhibitors (SSRIs) have become the most prescribed antidepressants in many countries. Although the SSRIs share a common mechanism of action, they differ substantially in their chemical structure, metabolism, and ...
A. Hemeryck, F. Belpaire
semanticscholar   +1 more source

Enantioselective N-Demethylation and Hydroxylation of Sibutramine in Human Liver Microsomes and Recombinant Cytochrome P-450 Isoforms

Journal of Toxicology and Environmental Health, Part A, 2014
Dhananjay Shinde, Min-Jung Kim, E. Jeong, Y. Kim, Ji-woo Lee, Jae-Gook Shin, Dong-Hyun Kim   +6 more
semanticscholar   +1 more source

EFFECTS OF FLAVONOIDS ISOLATED FROM SCUTELLARIAE RADIX ON CYTOCHROME P-450 ACTIVITIES IN HUMAN LIVER MICROSOMES

Journal of Toxicology and Environmental Health, Part A, 2002
Ji-Yeon Kim, Soo Yong Lee, Dong-Hyun Kim, Bok‐Ryang Kim, R. Park, Byung Mu Lee   +5 more
semanticscholar   +1 more source

Identification of Human Liver Cytochrome P-450 3A4 as the Enzyme Responsible for Fentanyl and Sufentanil N-Dealkylation

Anesthesia and Analgesia, 1996
T. Tateishi, Y. Krivoruk, Y. Ueng, A. J. Wood, F. Guengerich, M. Wood   +5 more
semanticscholar   +1 more source

Fatal intoxication cases: cytochrome P 450 2D6 and 2C19 genotype distributions

European Journal of Clinical Pharmacology, 2004
A. Zackrisson, Per Holmgren, A. Gladh, Johan Ahlner, Bertil Lindblom   +4 more
semanticscholar   +1 more source

Nadph-Cytochrome P-450 Reductase is Involved in Flunitrazepam Reductive Metabolism in Hep G2 and Hep 3b Cells

Journal of Toxicology and Environmental Health, Part A, 2004
F. Peng, Chaing Hsin-Hui, Tang Sheng-Hui, Chen Pei-chun, Lu Shao-Chun   +4 more
semanticscholar   +1 more source

Metabolism of thalidomide in human microsomes, cloned human cytochrome P‐450 isozymes, and Hansen’s disease patients

Journal of biochemical and molecular toxicology, 2000
S. Teo, P. Sabourin, K. O'Brien, K. Kook, S. Thomas   +4 more
semanticscholar   +1 more source