Results 1 to 10 of about 5,044 (130)

The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population [PDF]

Clinical and Experimental Hypertension, 2017
Numerous studies demonstrated an importance of cytochrome P-450 epoxygenase pathway of arachidonic acids metabolism for the pathogenesis of essential hypertension (EH).
Alexey Polonikov, Marina Bykanova, Irina Ponomarenko, Svetlana Sirotina, Anna Bocharova, Kseniya Vagaytseva, Vadim Stepanov, Mikhail Churnosov, Olga Bushueva, Maria Solodilova, Yaroslav Shvetsov, Vladimir Ivanov   +11 more
doaj   +2 more sources

Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses. [PDF]

PLoS ONE, 2016
Although Plasmodium vivax relapses are classically associated with hypnozoite activation, it has been proposed that a proportion of these cases are due to primaquine (PQ) treatment failure caused by polymorphisms in cytochrome P-450 2D6 (CYP2D6).
Ana Carolina Rios Silvino, Gabriel Luiz Costa, Flávia Carolina Faustino de Araújo, David Benjamin Ascher, Douglas Eduardo Valente Pires, Cor Jesus Fernandes Fontes, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito, Tais Nobrega Sousa   +8 more
doaj   +3 more sources

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine [PDF]

, 2019
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled ...
Andreozzi, F, Mannino, Gc, Sesti, G
core   +1 more source

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source

Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma [PDF]

, 2005
Background Cytochrome P450 (CYP) enzymes in epithelial cells lining the alimentary tract play an important role in both the elimination and activation of (pro-)carcinogens.
Ina Bergheim, Christiane Bode, Alexandr Parlesak, SA Sheweita, T Oyama, X Ding, LS Kaminsky, QY Zhang, WH Peters, JC Kolars, YJ Chun, A Pfrunder, TB White, R Hakkak, L Massaad, L Massaad, T Yokose, MM Bradford, JA Agundez, JA McKay, I De Waziers, RA McKinnon, MG Mercurio, E Eliasson, DE Feierman, RC Zangar, TA Kocarek, BW Futscher, J Hakkola, KT Kivisto   +29 more
core   +1 more source

Characterisation of CYP2C8, CYP2C9 and CYP2C19 polymorphisms in a Ghanaian population [PDF]

, 2009
Background Genetic influences on drug efficacy and tolerability are now widely known. Pharmacogenetics has thus become an expanding field with great potential for improving drug efficacy and reducing toxicity.
William Kudzi, Alexander NO Dodoo, Jeremy J Mills, JK Lamba, E Garcia-Martin, JA Goldstein, M Pirmohamed, S Gerbal-Chaloin, D Dai, U Yasar, JO Miners, HG Xie, C Martinez, S Sanderson, J van der Weide, N Bahadur, AC Allabi, M Hersberger, SBU Rower, AW Dreisbach, S Parikh, I Cavaco, U Yasar, A Weise, S Rower, MG Scordo, CL Crespi, K Takanashi, UI Schwarz, CR Lee, RI Shorr, RH White, SM De Morais, SM de Morais, JA Goldstein, C Dandara, EA Gaikovitch, JA Goldstein, H Fukushima-Uesaka, B Chowbay, K Grasmader, TR Einarson, J Lazarou, TM Bosch, C Adithan   +44 more
core   +1 more source

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future [PDF]

, 2019
Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies.
Corson, Timothy W., Park, Bomina
core   +1 more source

CYP2C8 status of patients with malaria influences selection of Plasmodium falciparum pfmdr1 Alleles after Amodiaquine-Artesunate treatment [PDF]

, 2013
info:eu-repo/semantics ...
Anders Björkman, Andreas Mårtensson, Cavaco, Gabrielle Fröberg, Gil, Gil, Holmgren, Holmgren, Humphreys, Isa Cavaco, José P. Gil, Li, Mwinyi Msellem, Mårtensson, Paganotti, Zhang   +15 more
core   +1 more source

Association of warfarin dose with genes involved in its action and metabolism [PDF]

, 2007
We report an extensive study of variability in genes encoding proteins that are believed to be involved in the action and biotransformation of warfarin.
Mia Wadelius, Leslie Y. Chen, Niclas Eriksson, Suzannah Bumpstead, Jilur Ghori, Claes Wadelius, David Bentley, Ralph McGinnis, Panos Deloukas, M Aiach, CL Aquilante, AA Arbini, KL Berkner, KL Berkner, L Bodin, D Cain, LY Chen, Y Chen, JM Cheverud, B Dahlbäck, AK Daly, RL D’Ambrosio, G D’Andrea, F Dudbridge, SB Gabriel, A Geick, C Geisen, RL Haining, W Huang, L Kaminsky, M Kohlmeier, H Kohnke, H Kohnke, SR Kristensen, C Landefeld, TB Larsen, SC Lee, JM Lehmann, H Li, T Li, R Loebstein, R Loebstein, C Morisseau, DR Nyholt, M Otagiri, G Palareti, JK Pritchard, AE Rettie, AE Rettie, MJ Rieder, S Rost, S Sanderson, J Saupe, EA Sconce, MG Scordo, E Shikata, CA Spek, N Sussman, H Takahashi, H Takahashi, H Takahashi, JF Heijden van der, M Vecsler, DL Veenstra, LE Visser, M Wadelius, M Wadelius, N Wajih, R Wallin, R Wallin, C Watala, SM Wu, HY Yuan, Z Zhang   +73 more
core   +1 more source

Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) [PDF]

, 2013
This item is under embargo for a period of 12 months from the date of publication, in accordance with the publisher's policy. ‘This is the peer reviewed version of the following article: Knights, K. M., Rowland, A. and Miners, J. O.
Knights, Kathleen Mary, Miners, John Oliver, Rowland, Andrew   +2 more
core   +1 more source