Cyclic pyrrole-imidazole polyamides targeted to the androgen response element [PDF]
, 2009 Hairpin pyrrole−imidazole (Py-Im) polyamides are a class of cell-permeable DNA-binding small molecules that can disrupt transcription factor−DNA binding and regulate endogenous gene expression.
Chenoweth, David M. +4 more
core +2 more sources
Pharmacology Research &Perspectives, Volume 12, Issue 5, October 2024.Proposed biotransformation pathways of aficamten in male humans. Abstract Aficamten, a cardiac myosin inhibitor, is being developed for the treatment of patients with symptomatic hypertrophic cardiomyopathy (HCM). The purpose of this study was to determine the absorption, metabolism, and excretion of aficamten.
Donghong Xu +6 more
wiley +1 more source
Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese [PDF]
, 2014 BACKGROUND: Cytochrome P450 (CYP) 2C19 is a very important drug metabolizing enzyme. Although the single nucleotide polymorphisms (SNPs) of CYP2C19 G681A and G636A have been suggested that they may increase the incidence of cardiovascular events, the ...
Dongliang Wang +6 more
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Pharmacogenetics in Type 2 Diabetes: Potential Implications for Clinical Practice [PDF]
, 2013 Pharmacogenetic research aims to study how genetic variation may influence drug efficacy and/or toxicity; pharmacogenomics expands this quest to the entire genome. Pharmacogenetic findings may help to uncover new drug targets, illuminate pathophysiology,
Florez, Jose Carlos, Huang, Chunmei
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Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition [PDF]
, 2016 Efavirenz pharmacokinetics is characterized by large between-subject variability, which determines both therapeutic response and adverse effects.
Bies, Robert R. +6 more
core +1 more source
Dose banding as an alternative to body surface area-based dosing of chemotherapeutic agents [PDF]
, 2012 Background: Dose banding is a recently suggested dosing method that uses predefined ranges (bands) of body surface area (BSA) to calculate each patients dose by using a single BSA-value per band.
Baker, S.D. (Sharyn) +5 more
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Inhibition of cytochrome P450 activities by extracts of 'Hyptis verticillata' Jacq. : assessment for potential HERB-drug interactions [PDF]
, 2018 Understanding the potential for adverse drug reactions (ADRs), from herb-drug interactions, is a key aspect of medicinal plant safety, with particular relevance for public health in countries where medicinal plant use is highly prevalent. We undertook an
Barker, James +6 more
core +2 more sources
Individualization of Immunosuppressive Therapy after Solid Organ Transplantation [PDF]
, 2014 __Abstract__ When an individual’s kidneys fail, there are three treatment options: hemodialysis, peritoneal dialysis or kidney transplantation. A successful kidney transplantation results in the best patient survival and a better quality of life ...
Bouamar, R. (Rachida)
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Interaktionen kardialer und antiretroviraler Medikation [PDF]
, 2018 Zusammenfassung: Neue therapeutische Optionen der hochaktiven antiretroviralen Therapie (HAART) haben die Morbidität und Mortalität von HIV-infizierten Patienten deutlich gesenkt, so dass nun vermehrt die altersspezifischen Erkrankungen manifest werden ...
Drewe, Jürgen, Egger, Sabin
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Enantiomers of methylenedioxy designer drugs : the role of cytochrome P450s and catechol-O-methyltransferase in their metabolism [PDF]
, 2009 In the presented studies, the CYP dependent, enantioselective N-dealkylation and demethylenation of the designer drugs MDMA (Ecstasy), MBDB (Eden), and MDEA (Eve) was investigated.
Meyer, Markus Robert
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