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Bacterial cytochrome P450 for oxidative halogenated biaryl coupling. [PDF]
ACS CatalPetriti V +8 more
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Phytochemistry, 1994
The present status of plant cytochrome P450 research is reviewed. A comparison of the properties of this group of cytochrome proteins with those of other microsomal b-type haem proteins is made. The range of reactions catalysed by P450s is discussed as well as recent progress in improving purification and reconstitution.
Alfred Zimmerlin +2 more
exaly +3 more sources
The present status of plant cytochrome P450 research is reviewed. A comparison of the properties of this group of cytochrome proteins with those of other microsomal b-type haem proteins is made. The range of reactions catalysed by P450s is discussed as well as recent progress in improving purification and reconstitution.
Alfred Zimmerlin +2 more
exaly +3 more sources
Cytochrome P450s and chemoprevention
Biochemical Society Transactions, 2000The cytochrome P450 mono-oxygenase system represents a major defence against chemical challenge from the environment, constituting part of an adaptive response mounted by an organism following exposure to harmful agents. Cytochrome P450s are also able to catalyse the activation of compounds to toxic products, and participate in a variety of essential ...
Henderson, C J, Sahraouei, A, Wolf, C R
openaire +3 more sources
Archives of Biochemistry and Biophysics, 1997
Tolbutamide methyl hydroxylation and S-warfarin 7-hydroxylation activities were reconstituted in systems containing recombinant human cytochrome P450 (P450 or CYP) 2C10(2C9) and the optimal conditions for the systems were compared with those of bufuralol 1'-hydroxylation by CYP1A1, theophylline 8-hydroxylation by CYP1A2, bufuralol 1'-hydroxylation by ...
Yamazaki, H +5 more
openaire +5 more sources
Tolbutamide methyl hydroxylation and S-warfarin 7-hydroxylation activities were reconstituted in systems containing recombinant human cytochrome P450 (P450 or CYP) 2C10(2C9) and the optimal conditions for the systems were compared with those of bufuralol 1'-hydroxylation by CYP1A1, theophylline 8-hydroxylation by CYP1A2, bufuralol 1'-hydroxylation by ...
Yamazaki, H +5 more
openaire +5 more sources
Current Drug Metabolism, 2009
The term fatty liver identifies a liver in which lipids account for more than 5% of the liver's wet weight. When fat accumulates, the lipids primarily stored as triglycerides (TG) result in steatosis and provide substrates for lipid peroxidation. Accumulation of neutral lipids in hepatocytes leads to micro- and macro-vesicular steatosis and to balloon ...
María José, Gómez-Lechón +2 more
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The term fatty liver identifies a liver in which lipids account for more than 5% of the liver's wet weight. When fat accumulates, the lipids primarily stored as triglycerides (TG) result in steatosis and provide substrates for lipid peroxidation. Accumulation of neutral lipids in hepatocytes leads to micro- and macro-vesicular steatosis and to balloon ...
María José, Gómez-Lechón +2 more
openaire +2 more sources
Drug Metabolism Reviews, 2004
The cytochrome P450 class of enzymes is an extremely important and complex group. It has a significant place in ADME (adsorption, distribution, metabolism, elimination) that those developing new dr...
Corwin, Hansch +3 more
openaire +2 more sources
The cytochrome P450 class of enzymes is an extremely important and complex group. It has a significant place in ADME (adsorption, distribution, metabolism, elimination) that those developing new dr...
Corwin, Hansch +3 more
openaire +2 more sources