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Spectral Analyses of Cytochromes P450
2003UV/Vis spectroscopy is the major means of identifying intact holocytochrome P450. The carbon monoxide complex of the intact ferrous hemoprotein exhibits a characteristic spectrum between 448 and 452 nm, considerably distinct from the usual Soret absorption peaks of hemoproteins.
John B. Schenkman, Ingela Jansson
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Cytochrome P450 Reconstitution Systems
2003Human liver microsomes contain multiple forms of cytochrome P450 (CYP or P450) that catalyze oxidation of a number of xenobiotic and endobiotic chemicals. Individual P450 forms have unique, but overlapping, substrate specificities. It is necessary to determine which P450s play more important roles in the oxidation of these chemicals.
Hiroshi Yamazaki, Tsutomu Shimada
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1991
Publisher Summary This chapter discusses the cytochrome P450 turnover. The hepatic microsomal hemoproteins, collectively termed as cytochrome P450, consist of a family of multiple isozymes, all of which recruit heme, as their essential prosthetic moiety. These hemoproteins are monomeric, containing one heme moiety per mole of enzyme.
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Publisher Summary This chapter discusses the cytochrome P450 turnover. The hepatic microsomal hemoproteins, collectively termed as cytochrome P450, consist of a family of multiple isozymes, all of which recruit heme, as their essential prosthetic moiety. These hemoproteins are monomeric, containing one heme moiety per mole of enzyme.
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Cytochrome P450 Monooxygenases in Biotechnology and Synthetic Biology.
Trends in Biotechnology, 2019V. Urlacher, M. Girhard
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Journal of Lipid Mediators and Cell Signalling, 1995
Michal L. Schwartzman, John C. McGiff
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Michal L. Schwartzman, John C. McGiff
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Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens.
Advances in Experimental Medicine and Biology, 2018F. Peter Guengerich, N. Avadhani
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Cytochrome P450 in Pharmacogenetics: An Update.
Advances in Pharmacology, 2018A. Tornio, J. Backman
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Cytochrome P450 and atherosclerosis
Clinical Pharmacology & Therapeutics, 1996openaire +3 more sources
Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
Drug Metabolism And Disposition, 2016Natalie C. Sadler +7 more
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