Results 111 to 120 of about 33,784 (307)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Deeply Branching c₆-like Cytochromes of Cyanobacteria

, 2016
The cyanobacterium Synechococcus sp. PCC 7002 carries two genes, petJ1 and petJ2, for proteins related to soluble, cytochrome c6 electron transfer proteins.
Kamil Tamiola (2240872), Andrzej Szczepaniak (665789), Wojciech Bialek (598311), Matthew Nelson (1902790), Toivo Kallas (2438206)   +4 more
core   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Prostatic Cytochromes [PDF]

Nature, 1961
L, HOPKINSON, F L, JACKSON
openaire   +2 more sources

Bioactivation of chemicals by cytochromes P450

, 2007
Most chemical carcinogens require metabolism to generate highly reactive intermediates that manifest their carcinogenicity following covalent interaction with DNA.
Ioannides, C.
core  

Purification and characterization of low potential c cytochromes from Desulfovibrio desulfuricans membranes

, 1986
Desulfovibrio desulfuricans grown in a lactate-sulfate medium produces, in addition to soluble cytochromes, c-type cytochromes which appear to be integral membrane proteins.
Pope, Daniel H., J.C. Salerno, Daniel H. Pope, Salerno, J.C., Kramer, Jeffrey F., Jeffrey F. Kramer   +5 more
core   +1 more source

Tyrosinase Driven‐Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy

Advanced Science, EarlyView.
This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang, Junteng Qiu, Yunfeng Lu, Yahui Song, Xinyu Zhou, Tianshun Duan, Xuanqi Peng, Caixia Yin, Cheng Gao, Ruibing Wang   +9 more
wiley   +1 more source

Electroenzymatic CO2 Reduction Using Formate Dehydrogenase: Direct and Mediated Catalysis

ChemElectroChem
The electrocatalytic reduction of carbon dioxide (CO2) to formate by the enzyme formate dehydrogenase (FDH) makes use of the enzyme's observed reversibility, offering a promising strategy for the mitigation of CO2 and the production of value‐added ...
Navendu Paul, Isabel Moura, Luísa B. Maia, Cristina M. Cordas, Jose J. G. Moura   +4 more
doaj   +1 more source

Spatiotemporal Control of Formation of Dynamic Protein Fiber Assemblies via Photophysical Effects of a Focused Laser Beam

Advanced Science, EarlyView.
Tightly focused laser irradiation can accumulate tubulin proteins at/around the laser focus, which leads to the formation of highly ordered microtubule assemblies. The assemblies can exhibit various dynamic behaviors such as radial motion, bundling, and flagella‐like rotation with motor protein and chemical energy, highlighting as a unique tool for ...
Hiroshi Y. Yoshikawa, Ren Shirata, Takuya Takeshige, Riki Yoshida, Fumika Kiryu, Kei Takano, Shuma Matsumoto, Reiji Kawanami, Natsumi Sawada, Chi‐Shiun Wu, Yang‐Hsin Shih, Hiromasa Niinomi, Takahisa Matsuzaki, Seiichiro Nakabayashi, Tomoaki Matsuura, Teruki Sugiyama, Ryuzo Kawamura   +16 more
wiley   +1 more source

Interaction of Cytochromes P450 with Flavodoxin: a theoretical study [PDF]

, 2013
Cytochromes P450 are diverse group of heme enzymes found in most species on Earth. In humans they are involved in metabolism of foreign compounds or steroids, bacteria employ cytochromes P450 for utilization of various hydrophobic substrates.
Culka, Martin
core