Results 21 to 30 of about 24,782 (251)

b-Type Cytochromes

Annual Review of Biochemistry, 1980
No abstract ...
von Jagow, Gerhard, Sebald, Walter
openaire   +3 more sources

Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b₅ Activity

Biomedicines, 2020
Herein, the in vitro metabolism of tyrosine kinase inhibitor cabozantinib, the drug used for the treatment of metastatic medullary thyroid cancer and advanced renal cell carcinoma, was studied using hepatic microsomal samples of different human donors ...
Radek Indra, Katarína Vavrová, Petr Pompach, Zbyněk Heger, Petr Hodek   +4 more
doaj   +1 more source

Metabolome and Transcriptome Analyses of Cucurbitacin Biosynthesis in Luffa (Luffa acutangula)

Frontiers in Plant Science, 2022
Cucurbitacins are extremely bitter compounds mainly present in Cucurbitaceae, where Luffa belongs. However, there is no comprehensive analysis of cucurbitacin biosynthesis in Luffa fruit.
Gangjun Zhao, Meng Wang, Caixia Luo, Junxing Li, Hao Gong, Xiaoming Zheng, Xiaoxi Liu, Jianning Luo, Haibin Wu, Haibin Wu   +9 more
doaj   +1 more source

Genome-enabled studies of anaerobic, nitrate-dependent iron oxidation in the chemolithoautotrophic bacterium Thiobacillus denitrificans

Frontiers in Microbiology, 2013
Thiobacillus denitrificans is a chemolithoautotrophic bacterium capable of anaerobic, nitrate-dependent U(IV) and Fe(II) oxidation, both of which can strongly influence the long-term efficacy of in situ reductive immobilization of uranium in contaminated
Harry R Beller, Peng eZhou, Peng eZhou, Tina C. Legler, Anu eChakicherla, Staci eKane, Tracy E. Letain, Peggy A. O'Day   +7 more
doaj   +1 more source

Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways. [PDF]

PLoS ONE, 2016
BACKGROUND:Benzo(a)pyrene (BaP), naphthalene (NPh), phenanthrene (Phe), benzo(a)antharacene (BeA), and benzo(b)fluoranthene (BeF) are known carcinogenic polyaryl hydrocarbons (PAHs) present in cigarette smoke.
Sabina Ranjit, Narasimha M Midde, Namita Sinha, Benjamin J Patters, Mohammad A Rahman, Theodore J Cory, P S S Rao, Santosh Kumar   +7 more
doaj   +1 more source

Metabolic engineering of cucurbitacins in Cucurbita pepo hairy roots

Frontiers in Plant Science, 2022
In this paper we show that metabolic engineering in Cucurbita pepo hairy roots can be used to both effectively increase and modify cucurbitacins. Cucurbitacins are highly-oxygenated triterpenoids originally described in the Cucurbitaceae family, but have
Aldo Almeida, Lemeng Dong, Theis H. Thorsen, Morten H. Raadam, Bekzod Khakimov, Natalia Carreno-Quintero, Sotirios C. Kampranis, Søren Bak   +7 more
doaj   +1 more source

In situ spectroscopy reveals that microorganisms in different phyla use different electron transfer biomolecules to respire aerobically on soluble iron

Frontiers in Microbiology, 2016
Absorbance spectra were collected on twelve different live microorganisms, representing six phyla, as they respired aerobically on soluble iron at pH 1.5.
Robert Blake, Micah D. Anthony, Jordan D. Bates, Theresa Hudson, Kamilya M. Hunter, Brionna J. King, Bria L. Landry, Megan L. Lewis, Richard G. Painter   +8 more
doaj   +1 more source

A cytochrome b561 with ferric reductase activity from the parasitic blood fluke, Schistosoma japonicum. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: Iron has an integral role in numerous cellular reactions and is required by virtually all organisms. In physiological conditions, iron is abundant in a largely insoluble ferric state.
Amber Glanfield, Donald P McManus, Danielle J Smyth, Erica M Lovas, Alex Loukas, Geoffrey N Gobert, Malcolm K Jones   +6 more
doaj   +1 more source

Immunosuppressive Effect of Polycyclic Aromatic Hydrocarbons by Induction of Apoptosis of pre-B Lymphocytes of Bone Marrow

Acta Medica, 2002
Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental pollutants, distinguished by genotoxic, hepatotoxic, nephrotoxic and immunotoxic effects.
Jakub Novosad, Zdeněk Fiala, Lenka Borská, Jan Krejsek   +3 more
doaj   +1 more source

Electron Flow From the Inner Membrane Towards the Cell Exterior in Geobacter sulfurreducens: Biochemical Characterization of Cytochrome CbcL

Frontiers in Microbiology, 2022
Exoelectrogenic microorganisms are in the spotlight due to their unique respiratory mechanisms and potential applications in distinct biotechnological fields, including bioremediation, bioenergy production and microbial electrosynthesis.
Jorge M. A. Antunes, Jorge M. A. Antunes, Marta A. Silva, Marta A. Silva, Carlos A. Salgueiro, Carlos A. Salgueiro, Leonor Morgado, Leonor Morgado   +7 more
doaj   +1 more source