Results 61 to 70 of about 437,615 (360)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

“The Meaning of His Life Was Work”: The Construction of Identities in the Oral Narratives of Older Czech Men

Gender Studies, 2016
This article explores the ways in which older Czech men construct their masculine identities. Profiting from the personal memories of individuals who witnessed dramatic social changes in 20th century Czechoslovakia, the study draws on eight oral ...
Slabáková Radmila Švaříčková
doaj   +1 more source

Pozice nespisovných variet ve stylu nové české literatury

Stylistyka, 2020
The tendency to operate freely with devices of all language varieties and with characteristic practices of various functional styles is one of the significant features of the literary style.
Peter Mareš
doaj   +1 more source

Evaluation of economic potential of business environment development by comparing sector differences: perspective of SMEs in the Czech Republic and Slovakia

, 2020
Research background: Improving business conditions and SME development are signs of a country?s macroeconomic stability. The issue of identifying and removing barriers to the development of firms in the SME segment is a priority in all countries with ...
J. Belas, B. Gavurová, Martin Čepel, M. Kubák   +3 more
semanticscholar   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Enhancing Corrosion Resistance and Mechanical Strength of 3D‐Printed Iron Polylactic Acid for Marine Applications via Laser Surface Texturing

Advanced Engineering Materials, EarlyView.
Laser surface texturing significantly improves the corrosion resistance and mechanical strength of 3D‐printed iron polylactic acid (Ir‐PLA) for marine applications. Optimal laser parameters reduce corrosion by 80% and enhance tensile strength by 25% and ductility by 15%.
Mohammad Rezayat, Mojtaba Karamimoghadam, Mohammadreza Lalegani Dezaki, Ali Zolfagharian, Giuseppe Casalino, Antonio Mateo, Mahdi Bodaghi   +6 more
wiley   +1 more source

Additive Manufacturing of Gradient Stiffness Honeycombs Using Thermoplastic Polyurethane Composite Material Variations

Advanced Engineering Materials, EarlyView.
By combining porous, solid, and carbon fiber‐reinforced thermoplastic polyurethane within a single 3D printed honeycomb structure, this current work achieved precise control over spatial stiffness while ensuring strong interlayer adhesion. The findings demonstrate enhanced energy absorption and densification strain, outperforming traditional uniform ...
Savvas Koltsakidis, Konstantinos Tsongas, Dimitrios Tzetzis   +2 more
wiley   +1 more source

Parallel corpus in analysing Czech spoken expressions and their equivalents in English, French, and Polish [PDF]

Linguistica Pragensia
This paper uses corpus data to analyse spoken expressions and discourse markers in Czech, applying these findings to corpus-based exercises for learners of Czech as a foreign language.
Adrian Jan Zasina
doaj   +1 more source

Challenges during Flash Lamp Annealing of Aerosol‐Deposited Barium Titanate Films

Advanced Engineering Materials, EarlyView.
Aerosol deposition is used to rapidly deposit barium titanate films with thicknesses ranging from 2 to 16 μm at room temperature, eliminating the need for further densification. However, to recover the electromechanical properties, annealing is required, which limits the usage of temperature‐sensitive substrates.
Michel Kuhfuß, Juliette Cardoletti, Udo R. Eckstein, Shaoxiong Xie, Alexander Martin, Ken‐ichi Kakimoto, Sebastjan Glinšek, Kyle G. Webber   +7 more
wiley   +1 more source