Results 31 to 40 of about 1,062,614 (301)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Prognostic Properties of the GOLD 2023 Classification System
International Journal of COPD, 2023 Kristian Brat,1– 3 Michal Svoboda,4 Jaromir Zatloukal,5,6 Marek Plutinsky,1,2 Eva Volakova,5,6 Patrice Popelkova,7,8 Barbora Novotna,9 Tomas Dvorak,10 Vladimir Koblizek11,12 1Department of Respiratory Diseases, University Hospital Brno, Brno, Czech ...
Brat K +8 more
doaj
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Corporate Interest Rates and the Financial Accelerator in the Czech Republic [PDF]
, 2008 We analyze the determinants of the corporate interest rates and the financial accelerator in the Czech Republic. Using a unique panel of 448 Czech firms from 1996 to 2002, we find that selected balance sheet indicators influence significantly the firm ...
Horváth, Roman +2 more
core +2 more sources
Human Resources Readiness for Industry 4.0
Journal of Open Innovation: Technology, Market and Complexity, 2019 Industry 4.0 is related to major changes, particularly in production. As such changes might have major implications for the labour market; the paper focuses on the assumptions of the human capital and its preparedness for Industry 4.0 in the Czech ...
Jaroslav Vrchota +4 more
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Right to Privacy of Employees in the Legal Practice of Courts in the Slovak Republic and the Czech Republic [PDF]
Societas et Iurisprudentia, 2014 The presented study focuses on the current issues of the right to privacy of employees in the legal practice of the courts in the Slovak Republic and the Czech Republic.
Filip Michalíček
doaj
Key movement forces in the dairy industry in the Czech Republic
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2004 The paper analyses key movement forces in the dairy industry in the Czech Republic and evaluates their importance in the industry and their influence on the following development of the dairy industry in the Czech Republic.The current most important key ...
Renata Černíková
doaj +1 more source
, 2014 The chapter provides basic information about the history and development of tourism in the Czech Republic from the socialism time till today. Main types of tourism in the country are presented and basic statistical data concerning total bed capacity, overnight stays, the share of foreign tourists, the level of employment in the tourism sector and ...
Šauer, M., Frantál, B. (Bohumil)
openaire +2 more sources