Results 51 to 60 of about 1,103,337 (246)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Déficit congénital en facteur VII révélé par une hémorragie post circoncision
The Pan African Medical Journal, 2019 Le facteur VII ou proconvertine est un facteur de la coagulation vitamine K-dépendant qui intervient dans la voie exogène de la coagulation. Le déficit constitutionnel en facteur VII est une maladie héréditaire de transmission autosomique récessive, très
Mariem Ettarfaoui +2 more
doaj +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Una teoría de las áreas monetarias óptimas
Cuadernos de Economía, 1999 Es evidente que las crisis periódicas de balanza de pagos seguirá siendo una característica integral del sistema conómico internacional mientras que las tasas de cambio fijas, los salarios y los niveles de precios rígidos impidan que los términos de ...
Mundell Robert A.
doaj
Modelo de vivienda social a partir del uso integral de la Guadua angustifolia Kunth para las zonas urbanas y rurales de Nicaragua [PDF]
, 2017 Según los estudios de déficit habitacional en América Latina del BID, En Nicaragua el 78 por ciento de las familias nicaragüenses no posee un hogar digno; según datos oficiales para el año 2017 el país enfrenta un déficit de Como respuesta ante esta ...
Bonilla Tijerino, Jorge Alberto
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The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Estudios de Deusto, 2014 Although the Margin of appreciation is characterized as a shadowy figure, if we investigate in the European Court of Human Rights jurisprudence we can draw a number of criteria that aim its application in the right to free elections as established in ...
Pablo Sánchez-Molina
doaj +1 more source
Tolerância ao estresse por déficit hídrico de genótipos de Brachiaria brizantha. [PDF]
, 2010 O conhecimento dos mecanismos fisiológicos de resposta às condições de estresse por déficit hídrico poderá auxiliar no desenvolvimento de gramíneas forrageiras mais eficientes no uso da água.
ALTOÉ, J. +3 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen +6 more
wiley +1 more source