Results 251 to 260 of about 940,856 (311)

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert   +13 more
wiley   +1 more source

Expanding the Methodological Repertoire in Institutional Ethnography: A Design Sociology Approach to Mapping and Visualizing Invisible Work

open access: yesCanadian Review of Sociology/Revue canadienne de sociologie, EarlyView.
ABSTRACT This article presents a novel methodological approach in which institutional ethnography borrows from design sociology. Although mapping is a core component of institutional ethnography, previous research highlights opportunities to further develop mapping techniques as both an analytical tool and a means of presenting research findings ...
Anna Isaksson
wiley   +1 more source

Expansion of the Phenotypic and Genotypic Spectrum for PRKAR1B‐Related Marbach–Schaaf Neurodevelopmental Syndrome: A Case Series

open access: yesClinical Genetics, EarlyView.
Comprehensive clinical description of 12 subjects with pathogenic PRKAR1B variants, including two heterozygous deletions supporting haploinsufficiency as a possible mechanism of disease, providing valuable insight into the pathophysiology of MASNS and setting a framework upon which to design future mechanistic studies of PKA signaling in brain ...
Sebastian Burkart   +17 more
wiley   +1 more source

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