Results 101 to 110 of about 5,053,999 (299)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

open access: yesBrain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga   +11 more
wiley   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert   +13 more
wiley   +1 more source

Expanding the Methodological Repertoire in Institutional Ethnography: A Design Sociology Approach to Mapping and Visualizing Invisible Work

open access: yesCanadian Review of Sociology/Revue canadienne de sociologie, EarlyView.
ABSTRACT This article presents a novel methodological approach in which institutional ethnography borrows from design sociology. Although mapping is a core component of institutional ethnography, previous research highlights opportunities to further develop mapping techniques as both an analytical tool and a means of presenting research findings ...
Anna Isaksson
wiley   +1 more source

Public willingness to pay for wetland restoration in the Canadian Prairie Pothole Region

open access: yesCanadian Journal of Agricultural Economics/Revue canadienne d'agroeconomie, EarlyView.
Abstract Wetlands play a crucial role in the agricultural landscapes of Canada's Prairie Pothole Region (PPR) but are being lost to agricultural and urban development. There is increased interest from governments and conservation organizations in restoring previously drained wetlands, but these projects are costly and associated with intangible ...
Liam Boldt   +3 more
wiley   +1 more source

Using miniaturized laboratory equipment and DNA barcoding to improve conservation genetics training and identify illegally traded species

open access: yesConservation Biology, EarlyView.
Abstract Illegal wildlife trade (IWT) is one of the largest global illegal activities, and it negatively affects biodiversity and sustainable development worldwide. DNA barcoding coupled with high‐throughput sequencing (i.e., metabarcoding) is useful in identifying taxa affected by IWT and has been used routinely for decades.
Maria Joana Ferreira da Silva   +9 more
wiley   +1 more source

L’apport du marketing territorial à la bonne gouvernance locale au MAROC :Cas de la province de Ouarzazate

open access: yesRevue Marocaine de Recherche en Management et Marketing, 2009
Le Marketing Territorial (MT) est un nouvel outil au service des collectivités locales afin d’assurer leur bonne gouvernance. En effet, le MT peut contribuer au développement local parla promotion de la chose locale, à la démocratie locale, au ...
Hassan AZOUAOUI,
doaj  

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