Results 111 to 120 of about 1,789,531 (269)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
An investigation of constraint-based risk management for collaborative design
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In the context of internationally challenging economic, design has been regarded as a key factor in assisting design and manufacturing companies to survive.
Ruan, Jian
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
An Improved Method of Failure Mode Analysis for Design Changes [PDF]
, 2009 Organised by: Cranfield UniversityCustomers and market changes behaviour are a large part of the product creation and modification. Though, design changes introduce new potential failures into the products.
Laurenti, R., Rozenfeld, H.
core
Game-Design-Driven Knowledge: When Prototypes Unpack and Reframe Conventions
, 2019 This paper explores the implications of conceiving, designing and prototyping location-based mobile games (LBMGs) that bridge the real and the digital into fascinating and unexpected hybrid worlds.
Ilaria Mariani +5 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 2010 Copyright @ 2010 Greenleaf PublishingEco-efficient Product-Service System (PSS) innovations represent a promising approach to sustainability. However the application of this concept is still very limited because eco-efficient PSS are intrinsically ...
CESCHIN, FABRIZIO, Ceschin, F
core
Towards a kansei-based user modeling methodology for eco-design [PDF]
, 2013 We propose here to highlight the benefits of building a framework linking Kansei Design (KD), User Centered Design (UCD) and Eco-design, as the correlation between these fields is barely explored in research at the current time.
AOUSSAT, Améziane +2 more
core
Set-based design of mechanical systems with design robustness integrated
, 2014 This paper presents a method for parameter design of mechanical products based on a set-based approach. Set-based concurrent engineering emphasises on designing in a multi-stakeholder environment with concurrent involvement of the stakeholders in the ...
DANTAN, Jean-Yves +3 more
core +1 more source