Results 171 to 180 of about 3,686,815 (268)

A designed hybrid pathway for efficient synthesis of D-pantothenate in E. coli

open access: hybrid
Chenkai Cao   +5 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

D-Finder 2: Towards Efficient Correctness of Incremental Design

open access: green, 2011
Saddek Bensalem   +5 more
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

The Need for Medical Device Batteries to Be Designed to Be Removable. [PDF]

open access: yesJ Diabetes Sci Technol
Brandt D, Klonoff DC, Heinemann L.
europepmc   +1 more source

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