Results 81 to 90 of about 3,683,967 (228)

Optimal Mechanisms for Single Machine Scheduling [PDF]

We study the design of optimal mechanisms in a setting where job-agents compete for being processed by a service provider that can handle one job at a time. Each job has a processing time and incurs a waiting cost. Jobs need to be compensated for waiting.
Heydenreich, Birgit, Mishra, Debasis, Müller, Rudolf, Uetz, Marc   +3 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Optimal design for goodness-of-fit of the Michaelis-Menten enzyme kinetic function [PDF]

We construct efficient designs for the Michaelis-Menten enzyme kinetic model capable of checking model assumption. An extended model, called EMAX model is also considered for this purpose.
Dette, Holger, Melas, Viatcheslav B., Wong, Weng Kee   +2 more
core  

Generalized Convolutional Neural Networks for Point Cloud Data

, 2017
The introduction of cheap RGB-D cameras, stereo cameras, and LIDAR devices has given the computer vision community 3D information that conventional RGB cameras cannot provide. This data is often stored as a point cloud.
Davis, Andrew, Savchenkov, Aleksandr, Zhao, Xuan   +2 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Safe Synthesis of 4,7-Dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine and Its SNAr Reactions

Molecules, 2018
A safe and efficient synthesis of 4,7-dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine from the commercial diaminomaleonitrile is reported. Conditions for selective aromatic nucleophilic substitution of one or two bromine atoms by oxygen and nitrogen ...
Timofey N. Chmovzh, Ekaterina A. Knyazeva, Konstantin A. Lyssenko, Vadim V. Popov, Oleg A. Rakitin   +4 more
doaj   +1 more source

San Marco D/L solar array system design and performance [PDF]

The design and performance of the solar array system for the San Marco D/L spacecraft is described in detail. The solar array system design is shown to be suitable for spacecraft which have elastically sensitized outer surfaces to measure aerodynamic ...
Agneni, A., Day, J. H., Jr., Diruscio, M.   +2 more
core   +1 more source

Development of D-Statcom in hardware in the loop system for voltage SAG mitigation [PDF]

, 2019
The problem of power quality (PQ) is of utmost concern today. The widespread use of electronic equipment such as adjustable speed drive (ASD), programmable logic controller (PLC), information technology equipment in power electronics applications such
Mohammed, Amjad Muneim
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source