Results 81 to 90 of about 25,056,407 (249)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Development of an Axial Flux MEMS BLDC Micromotor with Increased Efficiency and Power Density
Energies, 2015 This paper presents a rigorous design and optimization of an axial flux microelectromechanical systems (MEMS) brushless dc (BLDC) micromotor with dual rotor improving both efficiency and power density with an external diameter of only around 10 mm.
Xiaofeng Ding +5 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Animal, 2007 The experiment consisted of a 2 × 2 × 2 factorial design testing the two D+ and D− chicken lines selected for divergent digestion efficiency (fifth selection generation), xylanase (with or without) and ampicillin and collistin (with or without ...
V. García +4 more
doaj +1 more source
Design Education as a Catalyst for Change
, 2018 Designers play a role in shaping our world, both literally and figuratively. Human lives are spent interacting with designed artefacts, systems, and processes.
Mulder, Ingrid +9 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Creative problem-solving assessment and product design education
, 2018 This study reports findings from the administration of Creative Engineering Design Assessment (CEDA) to product design. The aim is to assess the applicability of CEDA in this discipline for the analysis of students’ level of creative problem-solving (CPS)
Oraklıbel, R. D. +2 more
core +1 more source
Robust D-Optimal Mixture Designs Under Manufacturing Tolerances via Multi-Objective NSGA-II
MathematicsThis study proposes a multi-objective optimization framework for generating statistically efficient and operationally robust designs in constrained mixture experiments with irregular experimental regions. In industrial settings, manufacturing variability
Wanida Limmun +2 more
doaj +1 more source
Applications of design theory for the constructions of MDS matrices for lightweight cryptography
Journal of Mathematical Cryptology, 2017 In this paper, we observe simple yet subtle interconnections among design theory, coding theory and cryptography. Maximum distance separable (MDS) matrices have applications not only in coding theory but are also of great importance in the design of ...
Gupta Kishan Chand +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source