Results 121 to 130 of about 1,665,022 (280)

Robust D-Optimal Mixture Designs Under Manufacturing Tolerances via Multi-Objective NSGA-II

Mathematics
This study proposes a multi-objective optimization framework for generating statistically efficient and operationally robust designs in constrained mixture experiments with irregular experimental regions. In industrial settings, manufacturing variability
Wanida Limmun, Boonorm Chomtee, John J. Borkowski   +2 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Thermal and hydrodynamic characteristics of Therminol VP-1 oil flow across perforated conical hollow turbulence promoter in Scheffler dish receiver tube

Scientific Reports
This study examines the thermal and hydrodynamic characteristics of Therminol VP-1 oil flow through perforated conical hollow-type turbulence promoters installed in a solar Scheffler dish collector receiver tube, utilizing computational fluid dynamics ...
Anil Kumar, Ram Kunwer, Nikhil Kanojia, Tabish Alam, Md Irfanul Haque Siddiqui, Dan Dobrota, Intesaaf Ashraf   +6 more
doaj   +1 more source

Impact of Digital Guidance on Accuracy, Reliability, and Time Efficiency of Wound Measurements

IEEE Open Journal of Instrumentation and Measurement
Wound size measurement is essential for clinical assessment, as it can indicate the patient’s healing progress and influence clinical decisions. Healthcare providers traditionally use physical wound measurement methods, such as rulers and digital ...
Dahlia Musa, Frank Guido-Sanz, Mindi Anderson, Desiree A. Diaz, Salam Daher   +4 more
doaj   +1 more source

The mechanics of progress in education : evidence from cross-country data [PDF]

The authors explore differences in education in rich and poor countries by first systematically documenting the relationship between per capita GNP and various indicators of educational development. They then exploit a simple accounting identity relating
Jee-Peng Tan, Mingat, Alain
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Pollution Regulation and the Efficiency Gains from Technological Innovation [PDF]

Previous studies suggest that emissions taxes are more efficient at stimulating the development of improved pollution abatement technologies than other policy instruments, such as (non-auctioned) tradable emissions permits.
Parry, Ian
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source