The role of gut microbiota‐derived metabolites in neuroinflammation
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
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Neonatal exposure to high D-galactose affects germ cell development in neonatal testes organ culture. [PDF]
Song H, Han MG, Lee R, Park HJ.
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Unprotected glycosyl pyridinium salts may be accessed in a single step from the corresponding unprotected sugar in aqueous solution. Whilst meta‐ and para‐substitution is well tolerated, ortho substitution of the N‐heterocycle inhibits product formation. Electrochemical studies revealed reduction potentials in the range of −0.9 to −1.4 V.
Daniel Chong+2 more
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Investigating the renoprotective effects of <i>Polygonatum sibiricum</i> polysaccharides (PSP) on D-galactose-induced aging mice: insights from gut microbiota and metabolomics analyses. [PDF]
Huang R, Che R, Sun T, Xie W, Zhang S.
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Glycoproteomics and Its Role in Understanding Bacterial O‐Linked Glycosylation
ABSTRACT Protein glycosylation is now recognized as a ubiquitous process observed in all domains of life. Within bacterial species, carbohydrates can be attached to multiple residues with glycosylation of serine, threonine, or tyrosine residues via their hydroxyl side chains referred to as O‐linked glycosylation.
Kristian I. Karlic+2 more
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Enhanced Cardiomyocyte NLRP3 Inflammasome-Mediated Pyroptosis Promotes d-Galactose-Induced Cardiac Aging. [PDF]
Liu WB+7 more
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ABSTRACT Collagen prolyl 4‐hydroxylase (C‐P4H) catalyzes the 4‐hydroxylation of Y‐prolines of the XYG‐repeat of procollagen. C‐P4Hs are tetrameric α2β2 enzymes. The α‐subunit provides the N‐terminal dimerization domain, the middle peptide‐substrate–binding (PSB) domain, and the C‐terminal catalytic (CAT) domain.
M. Mubinur Rahman+8 more
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Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using Lactiplantibacillus plantarum TY-Y10. [PDF]
Shi S+16 more
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PEARL: Protein Eluting Alginate with Recombinant Lactobacilli
Probiotic lactobacilli meet engineered living materials: This study introduces PEARL (protein eluting alginate with recombinant lactobacilli), an innovative engineered living material combining Lactiplantibacillus plantarum and alginate beads for controlled protein release.
Varun Sai Tadimarri+7 more
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miR‑34a induces apoptosis and pyroptosis in D‑Galactose‑induced aging cochlear hair cells via inhibiting TFAM and promoting mitochondrial dysfunction <i>in vitro</i> and <i>in vivo</i>. [PDF]
Wang Y+6 more
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