Results 171 to 180 of about 125,375 (195)

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection. [PDF]

Neurochem Res
Younis RL, El-Gohary RM, Ghalwash AA, Hegab II, Ghabrial MM, Aboshanady AM, Mostafa RA, El-Azeem AHA, Farghal EE, Belal AAE, Khattab H.   +10 more
europepmc   +1 more source

Cytoduction Preserves Genetic Diversity Following Plasmid Transfer Into Pooled Yeast Libraries

Yeast, EarlyView.
Unlike transformation, cytoduction (mating without nuclear fusion) is efficient at introducing plasmids into high‐diversity libraries with minimal impact on population diversity. ABSTRACT Introducing plasmids into yeast is a critical step for many phenotypic assays and genetic engineering applications.
Han‐Ying Jhuang, Dimitra Aggeli, Gregory I. Lang   +2 more
wiley   +1 more source

Chrysin mitigates neuronal apoptosis and impaired hippocampal neurogenesis in male rats subjected to D-galactose-induced brain aging. [PDF]

Biogerontology
Prajit R, Saenno R, Suwannakot K, Kaewngam S, Anosri T, Sritawan N, Aranarochana A, Sirichoat A, Pannangrong W, Wigmore P, Welbat JU.   +10 more
europepmc   +1 more source

Gut Microbiota Regulate Lipid Metabolism via the Bile Acid Pathway: Resistance to Hypoxia in Gansu Zokor (Eospalax cansus)

Integrative Zoology, EarlyView.
The gut microbiota regulates lipid metabolism of Gansu zokor (Eospalax cansus) through the bile acid pathway in hypoxic environments, reflecting the unique survival strategy of subterranean rodents to maintain lipid metabolism homeostasis and flexible energy metabolism in hypoxic environments.
Maohong Yang, Yingying Zhang, Zhuohang Li, Tianyi Liu, Jianping He, Jingang Li   +5 more
wiley   +1 more source

iTRAQ-Based Proteomic Profiling of Skin Aging Protective Effects of Tremella fuciformis-Derived Polysaccharides on D-Galactose-Induced Aging Mice. [PDF]

Molecules
Xu Y, Liu X, Guan J, Chen J, Xu X.
europepmc   +1 more source

Gut microbiota metabolism of branched‐chain amino acids and their metabolites can improve the physiological function of aging mice

Aging Cell, Volume 24, Issue 4, April 2025.
Parabacteroides merdae in gut microbiota metabolizes branched‐chain amino acids into isovalerate, 2‐methylbutyrate, and isobutyrate, with key gene porA being less abundant in unhealthy elderly. Parabacteroides merdae and its three BSCFAs improve physiological functions in aging mice, with preliminary mechanism exploration through microbiome ...
Hongchao Wang, Ling Feng, Zhangming Pei, Jianxin Zhao, Shourong Lu, Wenwei Lu   +5 more
wiley   +1 more source

Aging-induced dysbiosis worsens sepsis severity but is attenuated by probiotics in D-galactose-administered mice with cecal ligation and puncture model. [PDF]

PLoS One
Pinitchun C, Panpetch W, Bhunyakarnjanarat T, Udompornpitak K, Do HT, Visitchanakun P, Wannigama DL, Udomkarnjananun S, Sukprasansap M, Tencomnao T, Tangtanatakul P, Leelahavanichkul A.   +11 more
europepmc   +1 more source

Nuclear respiratory factor‐1 (NRF1) induction as a powerful strategy to deter mitochondrial dysfunction and senescence in mesenchymal stem cells

Aging Cell, Volume 24, Issue 4, April 2025.
Mitochondrial dysfunction is associated with senescence, the latter proving detrimental to mesenchymal stem cell (MSC)‐based strategies. We induced the expression of nuclear respiratory factor‐1 (NRF1), a driver of mitochondrial biogenesis, to metabolically potentiate MSCs and stave off senescence.
Hyunho Lee, Matteo Massaro, Nourhan Abdelfattah, Gherardo Baudo, Haoran Liu, Kyuson Yun, Elvin Blanco   +6 more
wiley   +1 more source