Results 181 to 190 of about 125,375 (195)

Cellular Senescence Contributes to the Dysfunction of Tight Junctions in Submandibular Glands of Aging Mice

open access: yesAging Cell, Volume 24, Issue 5, May 2025.
In aging mice, the submandibular gland, among the three major salivary glands (submandibular, parotid, and sublingual glands), shows a significant increase in senescent cells. This increase disrupts tight junction structures and is closely linked to aging‐related declines in salivary secretion.
Zhuo Chen   +8 more
wiley   +1 more source

Protective effects of a novel FS-Collagen hydrolysates against UV- and d-galactose-induced skin aging. [PDF]

open access: yesFood Sci Biotechnol
Zhang Y   +7 more
europepmc   +1 more source

CAV1 Exacerbates Renal Tubular Epithelial Cell Senescence by Suppressing CaMKK2/AMPK‐Mediated Autophagy

open access: yesAging Cell, Volume 24, Issue 5, May 2025.
This study revealed that the expression of CAV1 is increased in the renal tissues of D‐gal‐induced aging mice and human renal proximal tubular epithelial cells (HK‐2). Using a GST pull‐down assay, it was demonstrated that CAV1 can directly bind to CaMKK2 and inhibit its activity, thereby suppressing the AMPK‐mediated autophagy process and exacerbating ...
Liya Sun   +9 more
wiley   +1 more source

Transforming Growth Factor‐β‐Activated Protein 1 (TAK1) Regulates Necroptosis in Age‐Related Hearing Loss

open access: yesAging Cell, EarlyView.
TAK1‐mediated necroptotic pathways play an important role in the pathogenesis of ARHL. ABSTRACT Inflammation plays an important role in age‐related hearing loss (ARHL). Transforming growth factor‐β‐activated protein 1 (TAK1), a key factor upstream of inflammatory pathways, mediates various cell death pathways, potentially influencing the survival and ...
Hanjing Wang   +10 more
wiley   +1 more source

Dental pulp stem cells ameliorate D-galactose-induced cardiac ageing in rats. [PDF]

open access: yesPeerJ
El-Akabawy G   +11 more
europepmc   +1 more source

Phosphorylation of an RNA‐Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging

open access: yesAging Cell, EarlyView.
Evolutionary conserved Hippo/Mst1 signaling non‐canonically regulates the stability of mRNAs through directly phosphorylating a subset of RNA binding proteins to stabilize lipolytic mRNAs. Hpo pathway contributes to the regulation of Drosophila lifespan by modulating the expression and activity of Me31b/RCK, which subsequently affects mRNA levels of ...
Eunbyul Yeom   +26 more
wiley   +1 more source

Home - About - Disclaimer - Privacy