Results 61 to 70 of about 13,889,634 (275)

1H NMR study of lithium d-lactate

Solid State Nuclear Magnetic Resonance, 1992
Polycrystalline D-lactic acid lithium salt [(R)-2-hydroxypropanoic acid lithium salt, lithium D-lactate] has been investigated by pulsed proton magnetic resonance methods between 77 and 300 K at 25 MHz. The main relaxation mechanism is methyl rotation; the motion is characterized by an activation energy Ea = 14.5 +/- 0.5 kJ/mol and time factor tau 0 = (
Departments of Physics and Radiology, University of Florida, Gainesville, FL 32611, USA ( host institution ), Buszko, M.L. ( author ), Andrew, E.R. ( author )   +2 more
openaire   +3 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Methylglyoxal is a test for biological dysfunctions of homeostasis and endoecology, low cytosolic glucose level, and gluconeogenesis from fatty acids

Терапевтический архив, 2010
If a lot of carbohydrates cannot be in vivo stored as glycogen, the synthesis of palmitic fatty acid (FA) from glucose and its adipocyte deposition as triglycerides are under way in phylogenesis.
Vladimir Nikolaevich Titov, Leonid Fedorovich Dmitriev, Vyacheslav Vasil'evich Krylin, V N Titov, L F Dmitriyev, V A Krylin   +5 more
doaj  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Source, triggers and clinical implications of hyperlactemia in patients undergoing mitral valve surgery using Custodiol cardioplegia [PDF]

, 2013
Postoperative blood hyperlactaemia is an indicator of organ anaerobic metabolism and is associated with morbidity after cardiac surgery. This prospective study aims to explore the source, triggers and clinical implications for hyperlactaemia in patients ...
Zanchettin, Chiara, Angelini, Gianni D, Zoffoli, Giampaolo, Suleiman, M.Saadeh, Ascione, Raimondo, Polesel, Elvio, Mangino, Domenico, Venturini, Andrea   +7 more
core   +1 more source

Serum markers for early detection of patients with mesenteric ischemia after cardiac surgery

Innovative Surgical Sciences, 2018
Mesenteric ischemia (MESI) is a rare but often fatal complication in patients after cardiac surgery. Non-specific clinical symptoms and lack of specific laboratory parameters complicate the diagnosis.
Dohle Daniel-Sebastian, Bestendonk Carolin, Petrat Frank, Tsagakis Konstantinos, Wang Meng, Strucksberg Karl-Heinz, Canbay Ali, Jakob Heinz, de Groot Herbert   +8 more
doaj   +1 more source

Expression of Microbial Enzymes in Mammalian Astrocytes to Modulate Lactate Release

Brain Sciences, 2021
Astrocytes support and modulate neuronal activity through the release of L-lactate. The suggested roles of astrocytic lactate in the brain encompass an expanding range of vital functions, including central control of respiration and cardiovascular ...
Barbara Vaccari Cardoso, Iliana Barrera, Valentina Mosienko, Alexander V. Gourine, Sergey Kasparov, Anja G. Teschemacher   +5 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source