Results 41 to 50 of about 3,230,091 (259)
D-Optimal Designs for Binary and Weighted Linear Regression Models: One Design Variable
D-optimality is a well-known concept in experimental design that seeks to select an optimal set of design points to estimate the unknown parameters of a statistical model with a minimum variance.
Necla Gündüz, Bernard Torsney
doaj +1 more source
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
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ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi +5 more
wiley +1 more source
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye +33 more
wiley +1 more source
ABSTRACT Background Chronic limb‐threatening ischemia (CLTI) is a severe form of lower‐extremity artery disease characterized by distal lesions and microcirculatory impairment, limiting revascularization efficacy. Rheocarna is a direct hemoperfusion low‐density lipoprotein (LDL) adsorption device with potential rheological and anti‐inflammatory ...
Kunihiro Ishioka +12 more
wiley +1 more source
Nutritional and sensory quality of wheat bread supplemented with cassava and soybean flours
Sixteen composite flours were prepared using D-optimal constrained mixture design within a range of wheat 40–80%, cassava 10–30% and soybean 10–30% to optimize bread nutrient quality and sensory acceptability.
Haimanot H. Ayele +3 more
doaj +1 more source
D-optimal population designs in linear mixed effects models for multiple longitudinal data
The main purpose of this paper is to investigate D-optimal population designs in multi-response linear mixed models for longitudinal data. Observations of each response variable within subjects are assumed to have a first-order autoregressive structure ...
Hongyan Jiang, Rongxian Yue
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ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi +6 more
wiley +1 more source
Atovaquone smart lipid system: Design, statistical optimization, and in-vitro evaluation
The research was undertaken to design, develop and characterize the smart lipid system of an inadequate bioavailable Atovaquone (ATQ). The poor aqueous solubility and dissolution are the major constrain of inadequate bioavailability. The solubility study
Hardik Rana +3 more
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ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source

