Results 91 to 100 of about 24,776,592 (282)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Evaluation of Frequency Effects on Fatigue Life at High Test Frequencies for SAE 1045 Steel Based on Thermography and Electrical Resistance Measurements

Applied Sciences
This research provides a method for a reliable fatigue life estimation at high testing frequencies. The investigations are based on the lifetime prediction method StressLifeHCF considering test frequencies of 80 and 260 Hz for normalized SAE 1045 (C45E ...
Jonas Anton Ziman, Fabian Weber, Janina Koziol, Johannes Leon Otto, Lukas Maximilian Sauer, Frank Walther, Peter Starke   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Effect of the firing position on aiming error and probability of hit

Defence Technology, 2019
Sources of dispersions that contribute to delivery error and reduce the soldier performance in terms of hit probability are numerous. In order to improve the warfighter performance, the source of the errors contributing to the inaccuracy and dispersion ...
D. Corriveau, C.A. Rabbath, A. Goudreau
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Verfahrensdokumentation für FAB-D: Fullerton Advanced Balance Skala - deutsche Fassung

, 2011
Bei der FAB-D handelt es sich um eine motorische Testbatterie mit insgesamt 10 statischen und dynamischen Aufgaben zur Identifikation auch geringfügiger Unterschiede in den unterschiedlichen Dimensionen der posturalen Kontrolle bei älteren, selbständig ...
Schott, N.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Mechanistic machine learning for metamaterial fatigue strength design from first principles in additive manufacturing

Materials & Design
Digital control in manufacturing processes produces significant amounts of metadata. The production process metadata, such as thermal and optical measurements, enables a higher degree of property grading than uninstrumented manufacturing and feedback for
Mustafa Awd, Lobna Saeed, Sebastian Münstermann, Matthias Faes, Frank Walther   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source