Results 91 to 100 of about 1,741,164 (298)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Mending Fences with Self-Invalidation and Self-Downgrade [PDF]

Logical Methods in Computer Science, 2018
Cache coherence protocols based on self-invalidation and self-downgrade have recently seen increased popularity due to their simplicity, potential performance efficiency, and low energy consumption.
Parosh Aziz Abdulla, Mohamed Faouzi Atig, Stefanos Kaxiras, Carl Leonardsson, Alberto Ros, Yunyun Zhu   +5 more
doaj   +1 more source

Super-Yangian Y(gl(1|1)) and Its Oscillator Realization [PDF]

, 1996
On the basis of graded RTT formalism,the defining relation of the super-Yangian Y(gl(1|1)) is derived and its oscillator realization is constructed.Comment: 7 pages, latex, no figures, to appaer in the International Workshop on Frontiers in Quantum ...
Drinfeld V G, Frappat L, Ge M L, Guo-xing Ju, Han-ying Guo, Iohara K, Jin-fang Cai, Ke Wu, Khoroshkin S M, Khoroshkin S M, Khoroshkin S M, Kulish P, Leclair A, Liao L, Molev A, Molev A, Nazarov M L, Shi-kun Wang, Zhang R B, Zhang R B   +19 more
core   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Model Checking Spatial Logics for Closure Spaces [PDF]

Logical Methods in Computer Science, 2017
Spatial aspects of computation are becoming increasingly relevant in Computer Science, especially in the field of collective adaptive systems and when dealing with systems distributed in physical space. Traditional formal verification techniques are well
Vincenzo Ciancia, Diego Latella, Michele Loreti, Mieke Massink   +3 more
doaj   +1 more source

Transmission enhancement through square coaxial apertures arrays in metallic film: when leaky modes filter infrared light

, 2014
We consider arrays of square coaxial apertures in a gold layer and study their diffractive behavior in the far infrared region. These structures exhibit a resonant transmission enhancement that is used to design tunable bandpass filters.
Bedu, Frédéric, Commandré, Mireille, Dallaporta, Hervé, Demésy, Guillaume, Nicolet, André, Roux, Laurent, Tisserand, Stéphane, Vial, Benjamin, Zolla, Frédéric   +8 more
core   +3 more sources

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source