Results 111 to 120 of about 232,754 (286)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Systemic Crisis in the US-Turkish Relations Under the Presidency of D. Trump

open access: yesVestnik MGIMO-Universiteta, 2019
Relations between the United States and Turkey, the two military-political allies of the North Atlantic Treaty Organization (NATO), are experiencing an unprecedented crisis in their history.
A. A. Davydov
doaj   +1 more source

The problem of future contingents: scoping out a solution [PDF]

open access: yes, 2020
Various philosophers have long since been attracted to the doctrine that future contingent propositions systematically fail to be true—what is sometimes called the doctrine of the open future.
Todd, Patrick
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Global Competitiveness Potential of U.S. Nuclear Energy Technologies

open access: yesВестник Московского Университета. Серия XXV: Международные отношения и мировая политика
The new Trump administration considers the U.S. nuclear energy industry as one of the most important and promising tools for maintaining the country’s global leadership in the international arena.
T. V. Voronin
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Analyzing the Digital Traces of Political Manipulation: The 2016 Russian Interference Twitter Campaign

open access: yes, 2018
Until recently, social media was seen to promote democratic discourse on social and political issues. However, this powerful communication platform has come under scrutiny for allowing hostile actors to exploit online discussions in an attempt to ...
Badawy, Adam   +2 more
core   +1 more source

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