Results 211 to 220 of about 1,644,581 (293)

Constructing an indicator system for factors influencing volleyball coaches' in-game tactical decision-making: a Delphi study. [PDF]

Front Psychol
Sun Z, Zhang F.
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

In Utero Electroporation Uncovers an Early-Differentiating Subset of Dentate Gyrus Progenitors. [PDF]

Cell Mol Neurobiol
Shinohara HM, Takahashi T.
europepmc   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Assessing the neuroendocrine and psychological effects of acute everolimus administration in healthy male participants. [PDF]

Brain Behav Immun Health
Jacquet L, Friedel AL, Orth E, Reiser N, Hörbelt-Grünheidt T, Wiczoreck S, Witzke O, Schedlowski M, Jakobs M.   +8 more
europepmc   +1 more source

A model‐based analysis of the CYP2C9 genotype effects on fluconazole inhibition using flurbiprofen, ketoprofen and tolbutamide as probe drugs

British Journal of Pharmacology, EarlyView.
Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng, Darcy R. Flora, Mutaz M. Jaber, Allan E. Rettie, Richard C. Brundage, Timothy S. Tracy   +5 more
wiley   +1 more source

Localization of brain networks activated by acupuncture at anatomically adjacent acupoints in healthy participants: neuroimaging evidence and implications for migraine and stroke. [PDF]

Front Neurosci
Zhang Z, Ouyang X, Xie C, Zeng L, Fu Q, Yan Q, Wang T, Wang X, Zhao L.   +8 more
europepmc   +1 more source

Weaving a New Path: Rethinking Incumbents' Role in Sustainability Transitions Through a Multilevel Perspective

Creativity and Innovation Management, EarlyView.
ABSTRACT This study investigates how incumbent firms can actively foster sustainability transitions by strategically engaging across regime and niche levels when developing sustainable innovations. Drawing on an embedded case study of a leading Italian textile company involved in eight sustainable innovation projects, we identify four strategies—namely,
Maria Sofia Pugliese, Albachiara Boffelli, Mara Brumana, Matteo Kalchschmidt   +3 more
wiley   +1 more source

Cardiovascular disease risk and the balance between animal-based and plant-based foods, nutritional quality, and food processing level in the French NutriNet-Santé cohort: a longitudinal observational study. [PDF]

Lancet Reg Health Eur
Prioux C, Kesse-Guyot E, Srour B, Fézeu LK, Baudry J, Wagner S, Hercberg S, Touvier M, Allès B.   +8 more
europepmc   +1 more source

Tinkering Towards Sustainability: Bundling Innovations to Electrify the Fossil‐Dependent Process Industry

Creativity and Innovation Management, EarlyView.
ABSTRACT Sustainability transitions, such as electrifying the process industry, require a bundle of related innovations to make meaningful progress. Drawing on literature on innovation through tinkering, that is, adaptive, typically small‐scale experimentation with various forms of innovation, and applying a micropolitical perspective, this qualitative
Karin Wigger, Anna Yström, Alexander Gorgijevski, Viktor Werner   +3 more
wiley   +1 more source