Results 211 to 220 of about 147,924 (242)

Assessing healthcare organizations' readiness to implement a learning health system: questionnaire validation using a Delphi method. [PDF]

BMC Health Serv Res
Giroux CM, Bush PL, Alkhaldi M, Talla PK, Couturier Y, Thomas A, Bussières A, Wong ST, Poitras ME, Ahmed S.   +9 more
europepmc   +1 more source

Test Spacecraft [PDF]

, 2015
Fedotov, D. V., Gornostaev, A. A.
core  

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Nab-paclitaxel versus paclitaxel for taxane acute pain syndrome in solid tumors: a systematic review and meta-analysis. [PDF]

Front Oncol
Wei L, Li H, Wang Z.
europepmc   +1 more source

A model‐based analysis of the CYP2C9 genotype effects on fluconazole inhibition using flurbiprofen, ketoprofen and tolbutamide as probe drugs

British Journal of Pharmacology, EarlyView.
Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng, Darcy R. Flora, Mutaz M. Jaber, Allan E. Rettie, Richard C. Brundage, Timothy S. Tracy   +5 more
wiley   +1 more source

Central kisspeptin injection enhances food consumption in broiler chickens: role of opioidergic and dopaminergic receptors. [PDF]

Poult Sci
Zarei H, Radmehr M, Mohtasham A, Mehdipour M, Hasani K.   +4 more
europepmc   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala. [PDF]

Front Pharmacol
Broccoli L, Bernardi RE, Giannone F, Hoppe A, Jungling K, Borroto-Escuela DO, Rimondini-Giorgini R, Pérez de la Mora M, von Bohlen Und Halbach O, Fuxe K, Pape HC, Deussing JM, Spanagel R, Sommer WH, Hansson AC.   +14 more
europepmc   +1 more source

Tinkering Towards Sustainability: Bundling Innovations to Electrify the Fossil‐Dependent Process Industry

Creativity and Innovation Management, EarlyView.
ABSTRACT Sustainability transitions, such as electrifying the process industry, require a bundle of related innovations to make meaningful progress. Drawing on literature on innovation through tinkering, that is, adaptive, typically small‐scale experimentation with various forms of innovation, and applying a micropolitical perspective, this qualitative
Karin Wigger, Anna Yström, Alexander Gorgijevski, Viktor Werner   +3 more
wiley   +1 more source

Delayed onset of striatal projection neuron hyperexcitability in <i>Fmr1-/y</i> mice. [PDF]

Front Cell Neurosci
Nelson L, Janeček M, Matarazzo M, Shih YC, Peixoto RT.   +4 more
europepmc   +1 more source