Results 211 to 220 of about 58,912 (243)

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source

Brazilian version of the Cognitive Risk Profile for Pain Scale: translation, cross-cultural adaptation, and validation. [PDF]

Sao Paulo Med J
Trabulsi LMS, Dibai Filho AV, Pontes-Silva A, Jesus SFC, Mendes LP, Araujo GGC, Fidelis-de-Paula-Gomes CA, Bassi-Dibai D, Rêgo AS.   +8 more
europepmc   +1 more source

Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain

Epilepsia, EarlyView.
Abstract Objective Spreading depolarization (SD) is a phenomenon underlying various neurological conditions, including epilepsy. Researchers have suspected that local tissue oxygenation breakdown induces spontaneous SD. In this study, we investigated the relationship between spontaneous epileptic seizures and SD, with a focus on the role of local ...
Jiayang Liu, Bruce J. Gluckman
wiley   +1 more source

Knowledge, awareness, and practice of undergraduate medical students on Alzheimer's disease and dementia in Oman. [PDF]

J Educ Health Promot
Raj AP, Simon M, Bhat RM, Vaishnav R, Al Siyabi MY, Al Maamari YI, Amr M.   +6 more
europepmc   +1 more source

Fenfluramine in SCN1A‐related GEFS+: A multicenter observational study on efficacy, EEG improvement, and tolerability

Epilepsia Open, EarlyView.
Abstract The SCN1A gene is implicated in a broad spectrum of epilepsy phenotypes, ranging from self‐limited genetic epilepsy with febrile seizures plus (GEFS+) to severe developmental and epileptic encephalopathies such as Dravet syndrome (DS). While fenfluramine (FFA) has demonstrated strong efficacy in DS, its role in SCN1A‐related epilepsies beyond ...
Giovanni B. Dell'Isola, Alice Muda, Lucio Giordano, Renzo Guerrini, Alessandra Boncristiano, Nicola Pietrafusa, Maria Polselli, Francesca Bisulli, Francesca Ragona, Antonella Riva, Pasquale Striano, Domenica Immacolata Battaglia, Federico Vigevano   +12 more
wiley   +1 more source

Moderate densification and fertilization enhance water use efficiency in foxtail millet by optimizing water consumption partitioning. [PDF]

Front Plant Sci
Zheng J, Li Y, Liu T, Zhang L, He J, Dong K, Ren R, Chen Y, Yang T.   +8 more
europepmc   +1 more source

Regional Adjustments to NGA‐West2 Ground‐Motion Models for Turkey

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This paper presents a ground‐motion model updating (GMMU) framework to adjust NGA‐West2 models for predicting a set of intensity measures in Turkey, including peak ground acceleration (PGA), peak ground velocity (PGV), and pseudo‐spectral acceleration (PSA) at periods ranging from 0.01 to 10 s. The GMMU framework integrates bias identification
Mao‐Xin Wang, Gang Wang
wiley   +1 more source

Fluid Supplementation Therapy for Cerebrospinal Fluid Leakage Secondary to Thoracic Spinal Decompression Surgery-A Prospective Cohort Study. [PDF]

Global Spine J
Xu Z, Chen G, Yuan L, Wang L, Jiang S, Chu H, Guo Z, Qi Q, Chen Z, Li W, Zhou F, Sun C.   +11 more
europepmc   +1 more source

Numerical Simulation of Post‐Yield Hysteretic Behavior of Lap‐Spliced Reinforced Concrete Bridge Pier Walls Under Earthquake Loading

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Reinforced concrete pier walls designed before the 1970s often incorporate lap splice in potential plastic‐hinge regions. Previous experimental tests indicate that most of pier walls experienced post‐yield lap splice failure, necessitating a modeling approach that captures not only lap splice strength but also deformation capacity.
Gun Chan Lee, Sujith Mangalathu, Jong‐Su Jeon   +2 more
wiley   +1 more source

Development and internal validation of a nomogram for predicting pectoralis major fascia invasion in breast cancer patients using preoperative magnetic resonance imaging parameters. [PDF]

Gland Surg
Yu Z, Li K, Kang H.
europepmc   +1 more source