Results 31 to 40 of about 1,282 (157)

Regulation of the Growth‐Inhibitory Activity of Fhl1 via Interaction With Ifh1 and Crf1 at the Ribosomal Protein Gene Promoters in Saccharomyces cerevisiae

Genes to Cells, Volume 31, Issue 3, May 2026.
Under nutrient‐rich conditions, Ifh1 recruited to the RPG promoters by the FHA domain of Fhl1 promotes growth while masking the latent inhibitory activity of Fhl1. Upon starvation or stress, dissociation of Ifh1 exposes this inhibitory activity, restricting RPG transcription and cell proliferation, whereas Crf1 functions to mitigate excessive ...
Naoki Shimamura, Koji Kasahara
wiley   +1 more source

Randomised, Double‐Blinded, Placebo‐Controlled Challenge Test With Single Food Items in Dogs With Atopic Dermatitis and Adverse Food Reactions

Veterinary Dermatology, Volume 37, Issue 2, Page 247-256, April 2026.
ABSTRACT Background Identification of offending foods in dogs with adverse food reactions is usually based on “deterioration” during open food challenges. Objectives To examine the placebo effect during double‐blinded, placebo‐controlled food challenges using a predefined set of criteria for relapse.
Evi I. Sofou, Elisa Samuel, Svetlina Aleksandrova, Manolis Chatzis, Manolis N. Saridomichelakis   +4 more
wiley   +1 more source

Epitope Mapping of a Monoclonal Antibody Directed against Neisserial Heparin Binding Antigen Using Next Generation Sequencing of Antigen-Specific Libraries. [PDF]

PLoS ONE, 2016
We explore here the potential of a newly described technology, which is named PROFILER and is based on next generation sequencing of gene-specific lambda phage-displayed libraries, to rapidly and accurately map monoclonal antibody (mAb) epitopes.
Maria Domina, Veronica Lanza Cariccio, Salvatore Benfatto, Mario Venza, Isabella Venza, Danilo Donnarumma, Erika Bartolini, Erica Borgogni, Marco Bruttini, Laura Santini, Angelina Midiri, Roberta Galbo, Letizia Romeo, Francesco Patanè, Carmelo Biondo, Nathalie Norais, Vega Masignani, Giuseppe Teti, Franco Felici, Concetta Beninati   +19 more
doaj   +1 more source

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Emotion and reasoning in human decision-making

Economics: Journal Articles, 2019
Two systems in the brain that are involved in emotional and economic decision-making are described. The first is an evolutionarily old emotion-based system that operates on rewards defined by the genes such as food, warmth, social reputation, and having ...
Rolls Edmund T.
doaj   +1 more source

Consumers Engagement Toward Food Brands – The Case of Dairy Products

Folia Oeconomica Stetinensia, 2020
Research background: As food markets continue to develop the role and position of food consumers evolve as well. Food producers redefine their market strategies and focus on creating loyalty, building good contacts and consumers’ engagement towards ...
Gazdecki Michał, Goryńska-Goldmann Elżbieta   +1 more
doaj   +1 more source

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Teleological Empathy: A Comprehensive Journey Through Its Conceptualization, Functional Characteristics, Ethical Challenges and Future Perspectives in the Contemporary Social Sciences

Advances in Human-Computer Interaction, Volume 2026, Issue 1, 2026.
The rapid proliferation of generative artificial intelligence and automated systems has radically transformed human interaction, introducing emerging forms of functional affective expression that profoundly challenge traditional biological definitions.
Félix Oscar Socorro Márquez, Giovanni Efraín Reyes Ortiz, Marco Porta   +2 more
wiley   +1 more source

Naive calibration

Theoretical Economics, Volume 21, Issue 1, Page 44-70, January 2026.
We develop a model of non‐Bayesian decision‐making in which an agent obtains a signal about a relevant economic fundamental and subsequently takes an action. To interpret the signal, the agent calibrates a simple prediction rule based on a data set that consists of previous signals and state realizations.
Yair Antler, Benjamin Bachi
wiley   +1 more source

Alfabetismo financiero en jóvenes preparatorianos en la Zona Metropolitana del Valle de México

El Trimestre Económico, 2016
En este artículo medimos los niveles de alfabetismo financiero en estudiantes preparatorianos entre 15 y 18 años de edad, utilizando una encuesta basada en las metodologías de la Organización para la Cooperación y el Desarrollo Económico (OCDE) y de ...
F. Alejandro Villagómez
doaj