Structured Value Elimination with D-Separation Analysis
, 2010 In the last ten years, new models based on Bayesian Net- works (BN) emerged to handle large and complex systems. These new models can be divided in two: the unification with First Order Logic and uncertainty (Markov Logic Networks, Bayesian Logic) and Knowledge Base Construction Mod- els (Probabilistic Relational Models, Multy-Entity Bayesian Networks,
Torti, Lionel, Wuillemin, Pierre-Henri
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
High-Resolution IVIM MRI Characterizes Diffusion-Perfusion Properties of the Parasagittal Dura. [PDF]
NMR BiomedLiu YJ +8 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Advancing Early Breast Cancer Diagnosis and Ki-67 Expression Prediction With Ultrasound Viscoelastography: Based on Peritumoral Assessment. [PDF]
Health Sci RepHuang X +7 more
europepmc +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Perceptions of the value of higher education among undergraduate students
A rising tide of reports, commentaries, surveys, and studies seems to herald a crisis in higher education – a crisis frequently framed as a question of value.
Beit-Arie, Yali
core
Development to implementation to evaluation: step-by-step approach to embedding a clinical trial of a machine learning algorithm in the electronic health record. [PDF]
JAMIA OpenMorrison E +4 more
europepmc +1 more source