Results 71 to 80 of about 4,877,250 (248)

Patient-centered primary care for adults at high risk for AUDs: the Choosing Healthier Drinking Options In primary CarE (CHOICE) trial

Addiction Science & Clinical Practice, 2017
Background Most patients with alcohol use disorders (AUDs) never receive alcohol treatment, and experts have recommended management of AUDs in primary care.
Katharine A. Bradley, Evette Joy Ludman, Laura J. Chavez, Jennifer F. Bobb, Susan J. Ruedebusch, Carol E. Achtmeyer, Joseph O. Merrill, Andrew J. Saxon, Ryan M. Caldeiro, Diane M. Greenberg, Amy K. Lee, Julie E. Richards, Rachel M. Thomas, Theresa E. Matson, Emily C. Williams, Eric Hawkins, Gwen Lapham, Daniel R. Kivlahan   +17 more
doaj   +1 more source

From 1-D to 2-D fuzzy: A proof that interval-valued and complex-valued are the only distributive options

2015 Annual Conference of the North American Fuzzy Information Processing Society (NAFIPS) held jointly with 2015 5th World Conference on Soft Computing (WConSC), 2015
While the usual 1-D fuzzy logic has many successful applications, in some practical cases, it is desirable to come up with a more subtle way of representing expert uncertainty. A natural idea is to add additional information, i.e., to go from 1-D to 2-D (and multi-D) fuzzy logic.
Servin, Christian, Kreinovich, Vladik, Kosheleva, Olga   +2 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cleaner reactive dyeing of ramie fiber using ethyl acetate–liquid ammonia medium

Industrial Crops and Products
Liquid-ammonia (LA) dyeing is a promising, resource-efficient route for cellulosic coloration; however, its industrial adoption is hindered by poor dye exhaustion and fixation. We report an LA–ethyl acetate (EtOAc) co-solvent system for dyeing ramie with
Guangzong Wu, Yinghui Wang, Jianhua Xiong, Md. Nahid Pervez, Cheng Zhou, Lina Lin, Yingjie Cai, Bin Xiong   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Discrete-Choice Experiment Assessing the Patient Preferences and Real-World Experiences of Patients with Migraine in Japan

Neurology and Therapy
Introduction Migraine is a debilitating headache disorder with a high prevalence in Japan that imposes significant societal burden. Although the Japanese Clinical Practice Guideline for Headache Disorders 2021 recommends both acute and preventive ...
Takao Takeshima, Akira Yuasa, Yukie Michelle Lloyd, Louis Patrick Watanabe, Kazumasa Kamei, Akiho Terasawa, Josh Coulter, Lucy Abraham, Brett Hauber, Masahiro Iijima   +9 more
doaj   +1 more source

Understanding interoception across emotional contexts: development and validation of the Emotion-Linked Interoceptive Awareness Scale

Frontiers in Psychology
This research aimed to develop and validate the Emotion-Linked Interoceptive Awareness (ELIA) scale, a self-report measure assessing awareness of bodily sensations under specific emotional contexts, through four online studies.
Tomohiro Arai, Tomohiro Arai, Tomoko Komano, Hideki Ohira   +3 more
doaj   +1 more source

Sr²⁺ sorption property of seaweed-like sodium titanate mats: effects of crystallographic properties. [PDF]

RSC Adv, 2021
Kondo Y, Goto T, Sekino T.
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source