Results 91 to 100 of about 10,212,280 (356)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

An MCMC Approach to Universal Lossy Compression of Analog Sources

open access: yes, 2011
Motivated by the Markov chain Monte Carlo (MCMC) approach to the compression of discrete sources developed by Jalali and Weissman, we propose a lossy compression algorithm for analog sources that relies on a finite reproduction alphabet, which grows with
Baron, Dror, Weissman, Tsachy
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

An Innovative Optimization Strategy for Efficient Energy Management With Day-Ahead Demand Response Signal and Energy Consumption Forecasting in Smart Grid Using Artificial Neural Network

open access: yesIEEE Access, 2020
In this study, a novel framework is proposed for efficient energy management of residential buildings to reduce the electricity bill, alleviate peak-to-average ratio (PAR), and acquire the desired trade-off between the electricity bill and user ...
Ghulam Hafeez   +6 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Expanding Annular Domain Algorithm to Estimate Domains of Attraction for Power System Stability Analysis

open access: yesCSEE Journal of Power and Energy Systems
This paper presents an Expanding Annular Domain (EAD) algorithm combined with Sum of Squares (SOS) programming to estimate and maximize the domain of attraction (DA) of power systems.
Yuqing Lin   +3 more
doaj   +1 more source

New accountant job market reform by computer algorithm: an experimental study

open access: yesSHS Web of Conferences, 2017
The purpose of this study is to examine the matching of new accountants with accounting firms in Japan. A notable feature of the present study is that it brings a computer algorithm to the job-hiring task.
Hirose Yoshitaka
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

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