Results 111 to 120 of about 10,212,280 (356)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
On Exact and Approximate Solutions for Hard Problems: An Alternative Look [PDF]
We discuss in an informal, general audience style the da Costa-Doria conjecture about the independence of the P = NP hypothesis and try to briefly assess its impact on practical situations in economics.
A. Teixeira +4 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Das German Algorithm Project (GAP) und die Pharmakogenetik der Lithiumaugmentation
, 2010 Introduction: Standardized treatment regimes for the pharmacological treatment of depression have been proposed to minimize the rate of therapy resistant patients. The German Algorithm Project was established in three phases (GAP 1-3) to test the effectiveness of a standardized, stepwise treatment regime (SSTR) compared to treatment as usual (TAU ...
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Reduced-Complexity Deterministic Annealing for Vector Quantizer Design
EURASIP Journal on Advances in Signal Processing, 2005 This paper presents a reduced-complexity deterministic annealing (DA) approach for vector quantizer (VQ) design by using soft information processing with simplified assignment measures.
Ortega Antonio, Demirciler Kemal
doaj +1 more source
Data Science Journal, 2017 Incomplete data are ubiquitous in social sciences; as a consequence, available data are inefficient (ineffective) and often biased. In the literature, multiple imputation is known to be the standard method to handle missing data.
Masayoshi Takahashi
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Permanent magnet synchronous motor demagnetization fault diagnosis based on PCA-ISSA-PNN
Scientific ReportsAiming at the demagnetization fault problem of the permanent magnet synchronous motor (PMSM), a demagnetization fault diagnosis method based on the combination of the principal component analysis (PCA) algorithm, the improved sparrow search algorithm ...
Yinquan Yu +4 more
doaj +1 more source