Results 11 to 20 of about 46,312 (227)

Dabigatran Acylglucuronide, the Major Metabolite of Dabigatran, Shows a Weaker Anticoagulant Effect than Dabigatran [PDF]

Pharmaceutics, 2022
Dabigatran (DAB) is an orally administered thrombin inhibitor. Both DAB and its main metabolite dabigatran acylglucuronide (DABG) have established anticoagulant effects. Here, we aimed to compare the relative anticoagulant effects of DABG and DAB in humans.
Jong-Min Kim, Jihyeon Noh, Jin-Woo Park, Hyewon Chung, Kyoung-Ah Kim, Seung Bin Park, Jun-Seok Lee, Ji-Young Park   +7 more
openaire   +3 more sources

Dabigatran in Cerebral Sinus Vein Thrombosis and Thrombophilia

Life, 2022
Background and Purpose: Thrombophilic gene alterations are a major risk factor for cerebral sinus vein thrombosis (CSVT). Up to 30% of all patients with cerebral sinus vein thrombosis (CSVT) are found to have thrombophilic defects such as prothrombin ...
Lukas Kellermair, Matthias W. G. Zeller, Caterina Kulyk, Josef Tomasits, Tim J. von Oertzen, Milan R. Vosko   +5 more
doaj   +1 more source

Effects of dabigatran versus warfarin on 2-year cognitive outcomes in old patients with atrial fibrillation: results from the GIRAF randomized clinical trial

BMC Medicine, 2022
Observational studies support a role for oral anticoagulation to reduce the risk of dementia in atrial fibrillation patients, but conclusive data are lacking.
B. Caramelli, P. C. Yu, F. A. Cardozo, I. Magalhães, R. Spera, D. K. Amado, M. C. Escalante-Rojas, D. Gualandro, D. Calderaro, C. Tavares, Flávio A. Borges-Júnior, A. Pastana, M. Matheus, S. Brucki, A. C. Rodrigues, R. Nitrini, P. Caramelli   +16 more
semanticscholar   +1 more source

Direct Thrombin Inhibitor Dabigatran Compromises Pulmonary Endothelial Integrity in a Murine Model of Breast Cancer Metastasis to the Lungs; the Role of Platelets and Inflammation-Associated Haemostasis

Frontiers in Pharmacology, 2022
Activation of the coagulation cascade favours metastatic spread, but antithrombotic therapy might also have detrimental effects on cancer progression. In this study, we characterized the effects of dabigatran, a direct reversible thrombin inhibitor, on ...
M. Smęda, M. Stojak, K. Przyborowski, M. Sternak, Joanna Suraj‐Prażmowska, K. Kuś, K. Derszniak, A. Jasztal, A. Kij, Anna Kurpińska, Anna Kieronska-Rudek, K. Wojnar-Lason, E. Buczek, T. Mohaissen, S. Chłopicki   +14 more
semanticscholar   +1 more source

Patient safety and estimation of renal function in patients prescribed new oral anticoagulants for stroke prevention in atrial fibrillation [PDF]

, 2013
OBJECTIVE: In clinical trials of dabigatran and rivaroxaban for stroke prevention in atrial fibrillation (AF), drug eligibility and dosing were determined using the Cockcroft-Gault equation to estimate creatine clearance as a measure of renal function ...
Ashman, N, Green, L, Hull, SA, MacCallum, PK, Mathur, R, Morris, JK, Saja, K   +6 more
core   +2 more sources

Impact of Dabigatran Treatment on Rotation Thromboelastometry

Clinical and Applied Thrombosis/Hemostasis, 2021
A rapid and reliable assessment of the dabigatran effect is desirable in dabigatran treated patients with uncontrolled bleeding or before acute surgery.
Juraj Sokol MD, PhD, Frantisek Nehaj MD, Jela Ivankova RNDr, Michal Mokan MD, PhD, Jana Zolkova RNDr, Lenka Lisa MD, PhD, Ludmila Linekova MD, Marian Mokan MD, DSc, FRCP Edin, Jan Stasko MD, PhD   +8 more
doaj   +1 more source

Dabigatran etexilate tetrahydrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C34H41N7O5·4H2O (systematic name: ethyl 3-{[2-({4-[(Z)-amino-(hexyl-oxycarbonyl-imino)-meth-yl]anilino}meth-yl)-1-meth-yl-benzimidazole-5-carbon-yl]pyridin-2-yl-amino}-propano-ate tetra-hydrate), the benzene and pyridine rings form dihedral angles of 5.4 (1) and 43.8 (1)°, respectively, with the benzimidazole mean plane.
Hong-Qiang Liu, Wei-Guang Zhang, Zhi-Qiang Cai, Wei-Ren Xu, Xiu-Ping Shen   +4 more
openaire   +3 more sources

No influence of dabigatran anticoagulation on hemorrhagic transformation in an experimental model of ischemic stroke [PDF]

, 2012
Background: Dabigatran etexilate (DE) is a new oral direct thrombin inhibitor. Clinical trials point towards a favourable risk-to-benefit profile of DE compared to warfarin. In this study, we evaluated whether hemorrhagic transformation (HT) occurs after
Bohmann, Ferdinand, Förch, Christian, Lindhoff-Last, Edelgard, Mirceska, Ana, Pfeilschifter, Josef Martin (Prof. Dr.), Pfeilschifter, Waltraud, Steinmetz, Helmuth   +6 more
core   +7 more sources

Recanalization after cerebral venous thrombosis. A randomized controlled trial of the safety and efficacy of dabigatran etexilate versus dose-adjusted warfarin in patients with cerebral venous and dural sinus thrombosis

International Journal of Stroke, 2021
Background The effect of different anticoagulants on recanalization after cerebral venous thrombosis has not been studied in a randomized controlled trial.
J. Ferro, M. Bendszus, O. Jansen, J. Coutinho, F. Dentali, A. Kobayashi, D. Aguiar de Sousa, L. Neto, C. Miede, Jorge Caria, H. Huisman, H. Diener   +11 more
semanticscholar   +1 more source

The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects

Pharmacogenomics and Personalized Medicine, 2021
Dabigatran is a novel direct oral anticoagulant agent, whose plasma concentration is closely related to bleeding risk. Genetic polymorphisms can affect the level of plasma dabigatran.
Yue Liu, Chenguang Yang, Wenyuan Qi, Zuowei Pei, W. Xue, Huolan Zhu, Min Dong, Yingqiao Guo, Duanduan Cong, Fang Wang   +9 more
semanticscholar   +1 more source