Results 91 to 100 of about 14,647 (219)

Dicloxacillin is an inducer of intestinal P‐glycoprotein but neither dicloxacillin nor flucloxacillin increases the risk of stroke/systemic embolism in direct oral anticoagulant users

British Journal of Clinical Pharmacology, Volume 90, Issue 12, Page 3252-3262, December 2024.
Abstract Aim We aimed to assess if dicloxacillin/flucloxacillin reduces the therapeutic efficacy of direct oral anticoagulants (DOACs) and the underlying molecular mechanism. Methods In a randomized, crossover study, we assessed whether dicloxacillin reduces oral absorption of drugs through P‐glycoprotein (P‐gp) during 10 and 28 days of treatment.
Ditte B. Iversen, Ann‐Cathrine Dalgård Dunvald, Martin Thomsen Ernst, Shahab Abtahi, Patrick Souverein, Olaf Klungel, Glenn Brøde Jeppesen, Flemming Nielsen, Kim Brøsen, Helen S. Hammer, Oliver Pötz, Per Damkier, Erkka Järvinen, Anton Pottegård, Tore B. Stage   +14 more
wiley   +1 more source

IMPACT OF ABCB1 AND CES1 GENETIC POLYMORPHISMS ON TROUGH STEADY-STATE DABIGATRAN CONCENTRATIONS IN PATIENTS AFTER ENDOPROSTHESIS OF KNIFE JOIN

Атеротромбоз, 2018
Oral anticoagulants are widely used to prevent thromboembolic events in patients following total knee arthroplasty [1]. The genetic characteristics of patients affect the efficacy and safety of anticoagulants [2].
D. A. Sychev, A. N. Levanov, T. V. Shelekhova, P. O. Bochkov, N. Р. Denisenko, K. A. Ryzhikova, K. В. Mirzaev, E. A. Grishina, M. A. Gavrilov   +8 more
doaj   +1 more source

Ex-vivo Ex-Vivo Absorption Study of a Novel Dabigatran Etexilate Loaded Nanostructured Lipid Carrier Using Non-Everted Intestinal Sac Model

Iraqi Journal of Pharmaceutical Sciences, 2019
The purpose of our study was to develop Dabigatran Etexilate loaded nanostructured lipid carriers (DE-NLCs) using Glyceryl monostearate and Oleic acid as lipid matrix, and to estimate the potential of the developed delivery system to improve oral ...
haithem N Abed, Ahmed A. Hussein
doaj   +1 more source

Risks of oral anticoagulants: Analysis of adverse drug reactions reported to the Portuguese National Pharmacovigilance System

Pharmacology Research &Perspectives, Volume 12, Issue 5, October 2024.
Risks of oral anticoagulants: analysis of adverse drug reactions reported to the portuguese national pharmacovigilance system. Abstract Cardiovascular diseases are the leading cause of death globally, making the use of oral anticoagulants for prevention increasingly important. Historically, warfarin has played a significant role in this context.
Ana Sofia Martins, Cristina Monteiro, Ana Paula Duarte   +2 more
wiley   +1 more source

Acute Myocardial Infarction after Switching from Warfarin to Dabigatran

Oman Medical Journal, 2015
Dabigatran etexilate is a recently approved direct thrombin inhibitor (DTI), which is superior to warfarin in the prevention of stroke and systemic embolism in patients with atrial fibrillation (AF).
Wael Abuzeid, Hatim Al-Lawati, Neil Fam
doaj   +1 more source

Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

Drug Design, Development and Therapy, 2015
Michael R Preusch,1,2 Nicholas Ieronimakis,1 Errol S Wijelath,3 Sara Cabbage,1 Jerry Ricks,1 Florian Bea,2 Morayma Reyes,1 Joanne van Ryn,4 Michael E Rosenfeld1,5 1Department of Pathology, University of Washington, Seattle, WA, USA; 2Department of ...
Preusch MR, Ieronimakis N, Wijelath ES, Cabbage S, Ricks J, Bea F, Reyes M, van Ryn J, Rosenfeld ME   +8 more
doaj  

Dabigatran etexilate [PDF]

British Journal of Clinical Pharmacology, 2010
Eline A. Dubois, Adam F. Cohen
openaire   +3 more sources

Adverse events in patients initiated on dabigatran etexilate therapy in a pharmacist-managed anticoagulation clinic

Pharmacy Practice, 2013
Background: Vitamin K antagonists have been the treatment of choice in preventing thromboembolic events, but problems such as frequent dose adjustment and monitoring of coagulation status, including multiple drug and food interactions, make their use ...
Donaldson M, Norbeck AO
doaj  

The Complementary Effects of Dabigatran Etexilate and Exercise Training on the Development and Stability of the Atherosclerotic Lesions in Diabetic ApoE Knockout Mice. [PDF]

Pharmaceuticals (Basel), 2023
Kadoglou NP, Stasinopoulou M, Gkougkoudi E, Christodoulou E, Kostomitsopoulos N, Valsami G.   +5 more
europepmc   +1 more source

DABIGATRAN ETEXILATE IN ELDERL Y PATIENTS WITH ATRIAL FIBRILLATION: WHATS NEW?

Евразийский Кардиологический Журнал, 2017
The article discusses stroke prevention in elderly patients with atrial fibrillation. The principles of choosing anticoagulant therapy in this group of patients are discussed.
O. N. Tkacheva, N. M. Vorobyeva
doaj   +1 more source