Results 1 to 10 of about 11,145 (294)

Targeted systemic therapies for psoriatic arthritis: a systematic review and comparative synthesis of short-term articular, dermatological, enthesitis and dactylitis outcomes [PDF]

RMD Open, 2022
Introduction Randomised controlled trials (RCTs) have compared biological and targeted systemic disease-modifying antirheumatic drugs (DMARDS) against placebo in psoriatic arthritis (PsA); few have compared them head to head.
Iain B Mcinnes, Laura Marie Sawyer, Celia Sabry-Grant   +2 more
exaly   +3 more sources

Ixekizumab and complete resolution of enthesitis and dactylitis: integrated analysis of two phase 3 randomized trials in psoriatic arthritis [PDF]

Arthritis Research & Therapy, 2019
Background Ixekizumab improves signs/symptoms of psoriatic arthritis (PsA). We present an integrated analysis of baseline disease burden and post-baseline outcomes in ixekizumab-treated patients with enthesitis or dactylitis.
Dafna D. Gladman, Ana-Maria Orbai, Uta Klitz, James Cheng-Chung Wei, Gaia Gallo, Julie Birt, Suchitrita Rathmann, David Shrom, Helena Marzo-Ortega   +8 more
doaj   +3 more sources

Impact of guselkumab, an interleukin-23 p19 subunit inhibitor, on enthesitis and dactylitis in patients with moderate to severe psoriatic arthritis: results from a randomised, placebo-controlled, phase II study

RMD Open, 2020
Objective To evaluate the effect of guselkumab on enthesitis and dactylitis in a phase II trial of patients with active psoriatic arthritis (PsA).Methods This was a phase II, randomised, placebo-controlled, double-blind trial of adults with active PsA ...
Philip J Mease, Dafna D Gladman, Peter Nash   +2 more
exaly   +4 more sources

Psoriatic Dactylitis with Onychodystrophy

Journal of the Belgian Society of Radiology
Teaching point: Magnetic resonance imaging (MRI) and ultrasound may be useful to assess the extent of onychodystrophy associated with psoriatic dactylitis by showing nail bed thickening, matrix changes, and vascularity indicative of active inflammation.
Lucas Van Houtven, Filip M. Vanhoenacker
doaj   +6 more sources

Guselkumab, a Selective Interleukin‐23 p19 Subunit Inhibitor, Resolves Dactylitis in Patients With Active Psoriatic Arthritis: Pooled Results Through Week 52 From Two Phase 3 Studies

ACR Open Rheumatology, 2023
Objective Previous analyses of pooled DISCOVER‐1 and DISCOVER‐2 data through Week 24 showed significantly higher rates of dactylitis resolution in patients treated with guselkumab compared with placebo.
Dennis McGonagle, Iain B. McInnes, Atul Deodhar, Georg Schett, May Shawi, Soumya D. Chakravarty, Alexa P. Kollmeier, Xie L. Xu, Shihong Sheng, Stephen Xu, Christopher T. Ritchlin, Proton Rahman, Phillip J. Mease   +12 more
doaj   +2 more sources

Effect of tofacitinib on dactylitis and patient-reported outcomes in patients with active psoriatic arthritis: post-hoc analysis of phase III studies

BMC Rheumatology, 2022
Background Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA). This post-hoc analysis of two phase III studies in patients with PsA treated with tofacitinib assessed dactylitis by location, and the impact on ...
Ana-Maria Orbai, Philip J. Mease, Philip S. Helliwell, Oliver FitzGerald, Dona L. Fleishaker, Rajiv Mundayat, Pamela Young   +6 more
doaj   +2 more sources

Enthesitis and Dactylitis Resolution with Risankizumab for Active Psoriatic Arthritis: Integrated Analysis of the Randomized KEEPsAKE 1 and 2 Trials

Dermatology and Therapy
Introduction The presence (vs absence) of enthesitis/dactylitis is associated with greater psoriatic arthritis (PsA) activity and reduced health-related quality of life. Risankizumab, an interleukin 23 antagonist, demonstrated superior treatment efficacy
Shawn G. Kwatra, Saakshi Khattri, Ahmad Z. Amin, Roberto Ranza, Blair Kaplan, Linyu Shi, Byron Padilla, Ahmed M. Soliman, Dennis McGonagle   +8 more
doaj   +2 more sources

Dactilitis producida por sarcoidosis subcutánea como presentación de sarcoidosis

Actas Dermo-Sifiliográficas, 2023
Resumen: La dactilitis o dedo en salchicha, se define como la inflamación de uno o varios dedos de las manos o de los pies. La dactilitis sarcoidea es una forma poco frecuente de dactilitis, que suele ser debida a la afectación ósea granulomatosa a nivel
J. Marcoval, C. Llobera-Ris, C. Moreno-Vílchez, C. Torrecilla-Vall-Llossera, J. Sánchez Sánchez, J. Molinero Caturla   +5 more
doaj   +2 more sources

Validation of patient-reported outcome measures for dactylitis, psoriatic skin and nail disease, and uveitis in patients with psoriatic arthritis in routine care [PDF]

RMD Open
Background In routine care, Danish patients with psoriatic arthritis are monitored in the DANBIO registry. In March 2022, patient-reported outcome measures (PROMs) on selected non-musculoskeletal manifestations (NMM) were implemented.Aim To validate ...
Bente Glintborg, Merete Lund Hetland, Lene Dreyer, Lone Skov, Louise Majormoen Nielung   +4 more
doaj   +2 more sources

Correlation of clinical diagnosis of dactylitis by the dermatologist and ultrasonographic diagnosis by the rheumatologist in patients with psoriasis arthritis: Experience of a single clinic

Dermatologica Sinica, 2021
Background: Dactylitis is a characteristic feature of psoriatic arthritis (PsA). However, early diagnosis of mild dactylitis is challenging and image examination, such as ultrasonography (US), can be helpful.
Yang Lo, Ting- Shun Wang, Ko- Jen Li, Tsen- Fang Tsai   +3 more
doaj   +2 more sources