Results 191 to 200 of about 57,080 (289)

Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans. [PDF]

J Biomed Sci
Lin YH, Liao YH, Liao SB, Lin TY, Shanmugam MM, Hsu PJ, Chen CS, Ching TT, Wagner OI, Yuh CH, Wang HD.   +10 more
europepmc   +1 more source

Aging, Dauer, and Stature Phenotypes Are Conferred by Structure‐Directed Missense Mutations in the Endogenous AGE‐1/Phosphatidylinositol 3‐Kinase Catalytic Subunit

Aging Cell, Volume 25, Issue 6, June 2026.
Structure‐guided missense mutations in the C. elegans AGE‐1/PI3Kinase catalytic subunit and its LET‐60/Ras‐binding interface reveal separable signaling outputs from the Ras‐bound PI3K complex. Enhanced canonical catalytic activity, conferred by a gain‐of‐function mutation modeled on oncogenic human p110⍺ PI3K variants, promotes aging, reproductive ...
You Wu, Tam Duong, Neal R. Rasmussen, Kent L. Rossman, David J. Reiner   +4 more
wiley   +1 more source

Longitudinal Changes of Fundus Autofluorescence and Correlation With Visual Acuity in ABCA4-Associated Stargardt Disease. [PDF]

Invest Ophthalmol Vis Sci
Ibukun F, Strauss RW, Rustam Z, Khan MJ, Cideciyan AV, Birch DG, Ho A, Sunness JS, Audo IS, Michaelides M, Zrenner E, Traboulsi EI, Bernstein P, Sadda S, Ip MS, West S, Kong X.   +16 more
europepmc   +1 more source

Vitamin K2 Extends Lifespan by Alleviating Mitochondrial Stress via the JNK-1/SIR-2.1/DAF-16 Signaling Axis in Caenorhabditis elegans. [PDF]

Aging Cell
Guo SY, Li YQ, Piao H, Zheng WF, Li SQ, Liu ZY, Lv JT, Kong Y, Li QF, Wang YZ, Li SZ, Zhao CL, Li S.   +12 more
europepmc   +1 more source

DaF integriert [PDF]

, 2010
openaire   +1 more source

Whole Genome Analyses of the Endangered Northern Abalone (Haliotis kamtschatkana) Reveal Population Differentiation and a Genomic Signature of a Dramatic Population Decline

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT Despite widespread declines of many wildlife species, the effects of population decline on the genome and the recovery potential of affected species are still poorly understood, especially beyond a few charismatic species. The Northern abalone (or Pinto abalone; Haliotis kamtschatkana) is a marine gastropod mollusk of social, cultural and ...
Anna Tigano, Erin C. Herder, Kayla Long, Janine Supernault, Daniel L. Curtis, S. Christine Hansen, Mackenzie D. Mazur, Eric B. Rondeau, Dominique Bureau   +8 more
wiley   +1 more source

Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators. [PDF]

Aging Cell
Lalou A, Daskalaki I, Gkikas I, Rodríguez-López S, Morel JD, Benegiamo G, Faure A, Gao AW, Barmaz J, Wang Q, Li TY, Gao F, Broustail D, Schoonjans K, D'Angelo G, Auwerx J.   +15 more
europepmc   +1 more source

Redox Imbalance and NOS‐Dependent Modulation of Superoxide in the Bladder Mucosa of Women With IC/BPS: A Preliminary Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic condition characterized by bladder/pelvic pain and urinary symptoms, with poorly defined mechanisms and no reliable biomarkers. Oxidative stress, particularly reactive oxygen species (ROS), has been implicated in its pathophysiology, but direct human evidence remains scarce ...
Mariana G. de Oliveira, Edson Antunes, Gabriela Reolon Passos, Luiz Gustavo Oliveira Brito, Carlos Arturo Levi D'Ancona, Fabíola Z. Monica   +5 more
wiley   +1 more source

Mechanisms of Anti-Aging Effect of <i>Alpinia oxyphylla</i> Polysaccharides Mediated via IIS Pathway: Based on In Vivo Experiments, Network Pharmacology and Molecular Docking. [PDF]

Molecules
Chen T, Wang Y, Wu Y, Feng K, Wang Q, Lan Y, Zhu Q, Wu X, Sheng J, Zi C.   +9 more
europepmc   +1 more source

Tandemly duplicated TaERF109 genes confer drought tolerance and post‐drought recovery in wheat

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1744-1761, June 2026.
Tandemly duplicated TaERF109 transcription factor genes in wheat modulate growth traits and enhance drought tolerance by regulating the TaMADS56 transcription factor gene, cytokinin biosynthesis‐related genes, and nicotianamine synthase genes, revealing the critical role of tandemly duplicated genes in the coordination of stress responses and ...
Jun Chen, Shang Zhao, Wenjing Li, Chunxiao Wang, Yuan Gao, Zihan Yang, Yongbin Zhou, Ming Chen, Zhaoshi Xu, Youzhi Ma   +9 more
wiley   +1 more source