Results 241 to 250 of about 431,478 (301)

Anatomy of moist heatwaves in India during the summer monsoon season. [PDF]

Clim Dyn
Deoras A, Turner AG, Lekshmi S, Birch CE, Volonté A, Menon A, Schiemann RKH, Wilcox LJ.   +7 more
europepmc   +1 more source

Trends in Extreme Precipitation Events for the Northeastern United States 1948-2007 [PDF]

, 2010
Spierre, Susan G., Wake, Cameron P.
core   +2 more sources

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Fine-scale temporal and spatial dynamics of Ae. albopictus response to larviciding with Bacillus thuringiensis israelensis in Heidelberg, Germany. [PDF]

Sci Rep
Hatfield CRS, Stiles PC, Liyanage P, Baron JN, Rodriguez AT, Becker N, Zipf A, Beigl M, Rocklöv J.   +8 more
europepmc   +1 more source

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

The pH factor: unraveling drug-drug interactions in protein kinase inhibitors through the regulatory lens. [PDF]

Transl Clin Pharmacol
Stankeviciute S, Tsai A, Rayad N, Kruse M.   +3 more
europepmc   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Extracting public opinion on typhoon disasters in China: a sina weibo case study of landfalling typhoon Muifa (2022). [PDF]

Sci Rep
Sun Y, Wang Q, Zhu Y, Xu J, Liu L, Xiang C, Qian C.   +6 more
europepmc   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Influence of atmospheric rivers on precipitation variability in British Columbia's Gaat Héeni (Silver Salmon River) Watershed. [PDF]

Discov Atmos
Wittig DJ, Déry SJ.
europepmc   +1 more source