Results 91 to 100 of about 2,529 (215)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2008 In a 30 day feeding trial, daphnia and Artemia extracts were added to diets of juvenile Beluga (Huso huso) at different levels to evaluate its effects on growth and survival rate of the fish.
K. Darvish; M. Sodagar; M. Imanpor; A. Taheri
doaj
Refined crude glycerin in sow feed: A sustainable alternative
Acta Scientiarum: Animal SciencesThe objective of this work was to evaluate the effect of semi-purified glycerin added to the feed of pregnant and lactating sows on performance including dorsal diameter, body condition, daily weight gain, feed intake, and feed conversion rate.
Sandra de la Torre Iturbe +3 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A first-in-human phase 1 study of the SHP2 inhibitor BBP-398 in patients with advanced solid tumors
npj Precision OncologyBBP-398 is a selective allosteric SHP2 inhibitor designed to inhibit mitogen-activated protein kinase (MAPK) pathway–driven tumors. We performed the first-in-human phase 1 trial described herein to assess the safety, tolerability, pharmacokinetics, and ...
Gerald Falchook +14 more
doaj +1 more source
American Journal of Economic and Management Business (AJEMB)Research High-Calcium Natural Feed on Average Daily Gain, Survival Rate and Histopathogical Hepatopancreas and Intestine of Green Lobster (Panulirus Homarus) few have done so, even though this is important to observe and know. The aim is to find the food habit of green lobster, so that this information can be known to stake holders and can be a ...
Rita Rostika +2 more
openaire +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
BMC Musculoskeletal DisordersObjective The objective of this study is to investigate the application and outcomes of microsurgical nerve and vascular repair, replantation, and reconstruction in the management of severe hand injury.
Jian Liu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source