Results 21 to 30 of about 24,597 (148)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

The first, the next, and the cinematographed versions of AZT

open access: yesVitae, 2014
“Ronald Woodroof died of AIDS in September 12, 1992, seven years after he was diagnosed. A lower dose of AZT became widely used in later drug combinations that saved millions of lives”.
Paula C. JÍMENEZ
doaj  

Temporally Delayed Deployment of Photo‐Responsive Liquid Crystal Polymer Networks Toward Neural Interfaces

open access: yesAdvanced Healthcare Materials, EarlyView.
Deployable medical devices typically need external stimuli to trigger deployment. However, external stimuli are difficult to supply within tissues. Here, we describe a strategy to deploy small‐scale structures into soft tissues after insertion without the need for any stimulus. We demonstrate deployment within a tissue phantom.
Yeh‐Chia Tseng   +13 more
wiley   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

open access: yesAdvanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu   +12 more
wiley   +1 more source

Spartan Daily, September 14, 1977 [PDF]

open access: yes, 1977
Volume 69, Issue 7https://scholarworks.sjsu.edu/spartandaily/6230/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +3 more sources

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

open access: yesAdvanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo   +16 more
wiley   +1 more source

Los movimientos activistas del VIH/sida en el cine

open access: yesRevista de Medicina y Cine / Journal of Medicine and Movies, 2018
A principios de 1980 la irrupción del VIH/sida generó miedos, discriminación y estigmatización hacia personas ycolectivos afectados. Como respuesta, aparecieron movimientos activistas para defender los derechos de las personas con VIH/sida y promover la ...
Rafael CLUA GARCÍA et al.
doaj  

Spartan Daily, November 3, 1977 [PDF]

open access: yes, 1977
Volume 69, Issue 44https://scholarworks.sjsu.edu/spartandaily/6265/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

open access: yesAdvanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang   +9 more
wiley   +1 more source

Spartan Daily, December 8, 1949 [PDF]

open access: yes, 1948
Volume 38, Issue 43https://scholarworks.sjsu.edu/spartandaily/11310/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +2 more sources

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