Results 91 to 100 of about 1,281,664 (278)

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

A Passive Probe for Subsurface Oceans and Liquid Water in Jupiter's Icy Moons

, 2014
We describe an interferometric reflectometer method for passive detection of subsurface oceans and liquid water in Jovian icy moons using Jupiter's decametric radio emission (DAM).
Heggy, Essam, Liewer, Kurt, Maiwald, Frank, Ries, Paul, Romero-Wolf, Andrew, Vance, Steve   +5 more
core   +1 more source

Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1‐mediated P53 ubiquitination

Animal Models and Experimental Medicine, EarlyView.
Based on a dermis fibroblast Gorab knockout mouse model, this study revealed that Gorab deficiency promotes skin aging by influencing RCHY1, causing a decrease in P53 ubiquitination, damaging the activity of HDAC2, further resulting in the accumulation of aging‐related proteins (P53, P21, P16) and a reduction in extracellular matrix (ECM) components ...
Yanhong Li, Wei Liang, Yanfeng Xu, Yunlin Han, Wenjie Zhao, Siyuan Wang, Wei Deng, Chuan Qin   +7 more
wiley   +1 more source

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

Advanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐Escoto   +5 more
wiley   +1 more source

Role-Play Simulations and System Dynamics for Sustainability Solutions around Dams in New England [PDF]

, 2019
Research has shown that much of the science produced does not make its way to the decision-making table. This leads to a gap between scientific and societal progress, which is problematic.
Ashcraft, Catherine, Diessner, Natallia Leuchanka, Mo, Weiwei, Song, Cuihong   +3 more
core   +1 more source

Ontogenetic changes and sexual dimorphism in the cranium and mandible of the Atlantic walrus (Odobenus rosmarus rosmarus L.)

The Anatomical Record, EarlyView.
Abstract Walruses have been an important subsistence and cultural resource for humans and have been exploited for millennia across their distribution. This exploitation has contributed to severe declines in several populations and local extirpations.
Katrien Dierickx, Oliver Kersten, Youri van den Hurk, Brenna A. Frasier, Richard Sabin, Bastiaan Star, James H. Barrett   +6 more
wiley   +1 more source

Deep Learning- and Multi-Point Analysis-Based Systematic Deformation Warning for Arch Dams

Infrastructures
Deformation is a direct manifestation of structural changes that occur during the operation of arch dams, and the development of reliable deformation early warning indicators allows for their timely study.
Tao Zhou, Xiubo Niu, Ning Ma, Futing Sun, Shilin Gong   +4 more
doaj   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Fission of highly excited nuclei investigated in complete kinematic measurements

EPJ Web of Conferences, 2013
Fission is an extremely complex mechanism that requires a dynamical approach to describe the evolution of the process in terms of intrinsic and collective excitations of the nuclear constituents. In order to determine these effects a complex experimental
Rodríguez-Sánchez J.L., Benlliure J., Taieb J., Álvarez-Pol H., Audouin L., Ayyad Y., Bélier G., Boutoux G., Casarejos E., Chatillon A., Cortina-Gil D., Gorbinet T., Heinz A., Kelić-Heil A., Kurz N., Laurent B., Martin J.-F., Paradela C., Pellereau E., Pietras B., Prochazka A., Ramos D., Rodríguez-Tajes C., Rossi D., Simon H., Tassan-Got L., Vargas J., Voss B.   +27 more
doaj   +1 more source